Antenatal diagnosis of alobar holoprosencephaly

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dc.contributor.authorKhanna, Dollyen_US
dc.contributor.authorBhatti, Karandeep S.en_US
dc.date.accessioned2020-10-16T08:04:43Z
dc.date.available2020-10-16T08:04:43Z
dc.date.issued2020-05
dc.description.abstractHoloprosencephaly (HPE), a congenital induction disorder, occurs due to failed segmentation of neural tube and subsequent incomplete separation of the prosencephalon. Because of the defect in the ventral induction, HPE is also associated with multiple facial abnormalities. Mortality correlates with the severity of brain malformation and facial phenotype. Frequent causes of death include respiratory infections, dehydration due to uncontrolled diabetes insipidus, intractable seizures, and brainstem malfunction. This is a case of Alobar holoprosencephaly in the fetus of a 31-year-old G2P1 female, detected on level II obstetric ultrasound at 17 weeks of gestation. The objective of this case report is to discuss the etiology, pathogenesis, prenatal sonographic findings, management and prognosis of HPE which can aid in its early antenatal diagnosis and can help formulate an adequate plan for the parents and fetus.en_US
dc.identifier.affiliationsDepartment of Radiodiagnosis, Surjit Hospital, Amritsar, Punjab, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, Mrs. Khushbir Kalra Memorial Hospital, Amritsar, Punjab, Indiaen_US
dc.identifier.citationKhanna Dolly, Bhatti Karandeep S.. Antenatal diagnosis of alobar holoprosencephaly. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2020 May; 9(5): 2184-2186en_US
dc.identifier.issn2320-1770
dc.identifier.issn2320-1789
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/207722
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber5en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-1770.ijrcog20201832en_US
dc.subjectAlobaren_US
dc.subjectAntenatalen_US
dc.subjectFused thalamien_US
dc.subjectHolprosencephalyen_US
dc.subjectMonoventricleen_US
dc.subjectUltrasonographyen_US
dc.titleAntenatal diagnosis of alobar holoprosencephalyen_US
dc.typeJournal Articleen_US
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