Clinical features of systemic lupus erythematosus in Sri Lankan patients: results from a lupus clinic.

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dc.contributor.authorGalapatthy, Pen_US
dc.contributor.authorWazeel, A Nen_US
dc.contributor.authorNanayakkara, Sen_US
dc.contributor.authorSheriff, Ren_US
dc.date.accessioned2009-05-28T05:42:57Z
dc.date.available2009-05-28T05:42:57Z
dc.date.issued2000-12-11en_US
dc.descriptionThe Ceylon Medical Journal.en_US
dc.description.abstractOBJECTIVES: To find the common clinical features, pattern of visceral involvement, treatment received and outcome in patients diagnosed as having systemic lupus erythematosus (SLE) on American Rheumatological Association (ARA) criteria. SETTING: Clinic for patients referred or admitted to the University Medical Unit, National Hospital of Sri Lanka, Colombo, with diagnosed or suspected SLE. DESIGN AND METHODS: A prospective descriptive study. Clinical features of patients collected at time of registration in the clinic were maintained in a database. Patients were followed up prospectively and changes recorded. Data were analysed after 3 years of follow up. RESULTS: Of the 111 patients registered during this period, 96 (86%) were clinically diagnosed as having SLE. Of these, 77 patients (80%) satisfied ARA criteria for diagnosis of SLE. 72 were females (93%). The mean age of patients who satisfied the ARA criteria was 32 years (range 11 to 58), and the mean duration of disease 7 years (range 1 to 15). The commonest presentation was with mucocutaneous features (98%) and alopecia in 87%. Systemic features were found in 92% of patients. 67 (87%) of patients had visceral involvement with 60 (78%) having it at time of diagnosis. 53 (69%) had renal, 42 (54%) haematological, 33 (42%) neurological, 12 (16%) cardiac and 8 patients pulmonary involvement. Five patients died during the 3-year follow up and 2 developed chronic renal failure. Three patients underwent successful pregnancy after diagnosis of SLE. CONCLUSIONS: Our study confirmed the wide variability of clinical features seen in SLE. Alopecia and visceral involvement were common in Sri Lankan patients.en_US
dc.description.affiliationDepartment of Pharmacology, Faculty of Medicine, University of Colombo.en_US
dc.identifier.citationGalapatthy P, Wazeel AN, Nanayakkara S, Sheriff R. Clinical features of systemic lupus erythematosus in Sri Lankan patients: results from a lupus clinic. The Ceylon Medical Journal. 2000 Dec; 45(4): 162-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/48922
dc.language.isoengen_US
dc.source.urihttps://www.infolanka.com/CMJhome/en_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Distributionen_US
dc.subject.meshAmbulatory Care Facilitiesen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunosuppressive Agents --administration & dosageen_US
dc.subject.meshIncidenceen_US
dc.subject.meshLupus Erythematosus, Systemic --diagnosisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshSex Distributionen_US
dc.subject.meshSri Lanka --epidemiologyen_US
dc.subject.meshSurvival Rateen_US
dc.titleClinical features of systemic lupus erythematosus in Sri Lankan patients: results from a lupus clinic.en_US
dc.typeJournal Articleen_US
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