Distribution of acid and alkaline deoxyribonucleases in white and grey matter regions of growing and aging chick brain.
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Date
1979-03
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Abstract
The activities of acid and alkaline deoxyribonucleases in the white and
grey matter areas of growing and old chick cerebrum were measured. Two marker
enzymes for glial cells, butyrylcholinesterase and carbonic anhydrase were also
measured in these regions. Higher specific activities of both butyrylcholinesterase
and carbonic anhydrase were found in the white matter region at all the stages studied.
Acid and alkaline deoxyribonuclease activities were observed in both white and grey
matter. The decrease in the specific activity of acid deoxyribonuclease with advancement
of age was more pronounced as compared to the alkaline deoxyribonuclease
Marked reduction in total acid deoxyribonuclease activity in white matter, beyond
the age of 130 days, was observed. On the other hand, total alkaline deoxyribonuclease
activity in both white and grey matter continued to increase with age
Further, the activity per mg of DNA also increased in white matter of the old brain.
These results indirectly suggest a continued role for alkaline deoxyribonuclease in
glial cells formed at a later age.
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Keywords
Acid deoxyribonucleases, alkaline deoxyribonucleases, aging, chick brain
Citation
Rao K Subba, Shrivastaw K P. Distribution of acid and alkaline deoxyribonucleases in white and grey matter regions of growing and aging chick brain. Journal of Biosciences. 1979 Mar; 1(1): 69-74.