Diclofenac Topical Gel for the Management of Osteoarthritis and Joint Pain: Real Therapeutic Effect or Just Psychological Effect

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dc.contributor.authorChinnaswami, Ken_US
dc.contributor.authorHegde, Aen_US
dc.contributor.authorDavis, Den_US
dc.contributor.authorRaffic, Men_US
dc.contributor.authorSrampickal, GMen_US
dc.contributor.authorKumar, SSen_US
dc.contributor.authorGeorge, MJ.en_US
dc.date.accessioned2025-05-12T08:15:07Z
dc.date.available2025-05-12T08:15:07Z
dc.date.issued2024-12
dc.description.abstractDiclofenac topical gel is an effective treatment for osteoarthritis (OA) and joint pain due to its enhanced skin penetration and therapeutic benefits. The gel formulation provides a higher flux, allowing better penetration and absorption into underlying tissues than other formulations such as solutions or patches. Upon application, diclofenac reaches therapeutic levels in deeper tissues, including synovial fluid, which helps alleviate pain and inflammation while reducing systemic side effects, which are a major concern for OA patients with comorbid conditions. The sustained release mechanism of the gel maintains therapeutic levels over time, contributing to prolonged pain relief. In addition, combination formulations incorporating penetration enhancers or active ingredients can further boost the efficacy of diclofenac gel. Moreover, diclofenac gel demonstrates therapeutic benefits, with measurable pain relief and anti-inflammatory effects, making it a preferred choice of clinicians. However, topical counterirritants provide a paradoxical pain-relieving effect and caution is needed as topical analgesics with counterirritants, such as capsaicin, can cause severe skin injuries, including chemical burns.en_US
dc.identifier.affiliationsConsultant, Department of Orthopaedics, Royal Care Hospital, Coimbatore, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsProfessor and Head, Department of Orthopaedics, Kasturba Medical College, Mangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsAssociate Professor, Department of Orthopaedics, Amala Hospital, Thrissur, Kerala, Indiaen_US
dc.identifier.affiliationsProfessor and HOD, Department of Orthopaedics, Sree Gokulam Medical College, Trivandrum, Kerala, Indiaen_US
dc.identifier.affiliationsOrthopaedic and Joint Replacement Surgeon, Department of Orthopaedics, Providence Hospital, Alappuzha, Kerala, Indiaen_US
dc.identifier.affiliationsAssociate Professor, Department of Orthopaedics, Sree Gokulam Medical College, Trivandrum, Thiruvananthapuram, Kerala, Indiaen_US
dc.identifier.affiliationsProfessor and Unit Chief, Department of Orthopaedics, MOSC Medical College, Kochi, Kerala, Indiaen_US
dc.identifier.citationChinnaswami K, Hegde A, Davis D, Raffic M, Srampickal GM, Kumar SS, George MJ. . Diclofenac Topical Gel for the Management of Osteoarthritis and Joint Pain: Real Therapeutic Effect or Just Psychological Effect. International Journal of Scientific Study. 2024 Dec; 12(9): 1-9en_US
dc.identifier.issn2321-6379
dc.identifier.issn2321-595X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246955
dc.languageenen_US
dc.publisherInternational Research Organization for Life & Health Sciencesen_US
dc.relation.issuenumber9en_US
dc.relation.volume12en_US
dc.source.urihttps://www.ijss-sn.com/uploads/2/0/1/5/20153321/01_ijss_dec_24_ra01_-_2024.pdfen_US
dc.subjectCounterirritantsen_US
dc.subjectDiclofenac topical gelen_US
dc.subjectOsteoarthritisen_US
dc.subjectSkin penetrationen_US
dc.subjectTherapeutic efficacyen_US
dc.titleDiclofenac Topical Gel for the Management of Osteoarthritis and Joint Pain: Real Therapeutic Effect or Just Psychological Effecten_US
dc.typeJournal Articleen_US
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