Percutaneous transseptal mitral commissurotomy in pregnant women with critical mitral stenosis.

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dc.contributor.authorMishra, Sen_US
dc.contributor.authorNarang, Ren_US
dc.contributor.authorSharma, Men_US
dc.contributor.authorChopra, Aen_US
dc.contributor.authorSeth, Sen_US
dc.contributor.authorRamamurthy, Sen_US
dc.contributor.authorPrabhakaran, Den_US
dc.contributor.authorGoswami, K Cen_US
dc.contributor.authorTalwar, K Ken_US
dc.contributor.authorManchanda, S Cen_US
dc.contributor.authorBahl, V Ken_US
dc.date.accessioned2001-03-29en_US
dc.date.accessioned2009-05-27T04:27:48Z
dc.date.available2001-03-29en_US
dc.date.available2009-05-27T04:27:48Z
dc.date.issued2001-03-29en_US
dc.description.abstractBACKGROUND: Percutaneous transseptal mitral commissurotomy has been successfully performed in selected pregnant patients with severe symptomatic mitral stenosis. Its safety and efficacy needs to be evaluated in a large number of cases. METHODS AND RESULTS: Percutaneous transseptal mitral commissurotomy was performed in 85 severely symptomatic (New York Heart Association functional class III or IV) pregnant women aged 22.7+/-4.1 years (range 18-39 years) with critical mitral stenosis at 24.8+/-4.7 weeks (range 20-34 weeks) of gestation. Percutaneous valvotomy was performed using a flow-guided Inoue balloon in all the patients. The procedure was considered successful in 80 (94%) patients. The hemodynamic mean end-diastolic gradient decreased from 26.7+/-6.8 mm Hg (range 16-35 mmHg) to 4.5+/-3.8 mmHg (range 0-14 mmHg) (p<0.001). The mean diastolic gradient decreased from 29.1+/-9.1 mmHg (range 18-38 mmHg) to 7.2+/-4.1 mmHg (range 4.1-18 mmHg) (p<0.001). The mean mitral valve area assessed by echocardiography increased from 0.75+/-0.5 cm2 (range 0.4-1.0 cm2) to 2.0+/-0.5 (range 1.0-2.7 cm2) (p<0.001). The mean fluoroscopy time was 3.6+/-3.2 minutes. The results of the mitral valvotomy were considered suboptimal in 4 patients. Mitral regurgitation increased by 1 grade in 16 patients and more than 2 grades in 2 patients. One patient developed pericardial tamponade during the procedure and was managed by catheter drainage. Percutaneous mitral valve dilatation was then successfully performed in this patient. No fetal abortion occurred after the procedure. CONCLUSIONS: The results of this study indicate that percutaneous transseptal mitral commissurotomy is a safe and effective procedure for severe symptomatic mitral stenosis in pregnancy.en_US
dc.description.affiliationDepartment of Cardiology, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationMishra S, Narang R, Sharma M, Chopra A, Seth S, Ramamurthy S, Prabhakaran D, Goswami KC, Talwar KK, Manchanda SC, Bahl VK. Percutaneous transseptal mitral commissurotomy in pregnant women with critical mitral stenosis. Indian Heart Journal. 2001 Mar-Apr; 53(2): 192-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/5519
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBalloon Dilatation --methodsen_US
dc.subject.meshEchocardiography --methodsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshHeart Function Testsen_US
dc.subject.meshHemodynamics --physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMitral Valve Stenosis --therapyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Complications, Cardiovascular --therapyen_US
dc.subject.meshPregnancy Outcomeen_US
dc.subject.meshProbabilityen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshUltrasonography, Doppler --methodsen_US
dc.subject.meshUltrasonography, Prenatal --methodsen_US
dc.titlePercutaneous transseptal mitral commissurotomy in pregnant women with critical mitral stenosis.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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