Effect of dexamethasone with granisetron or ondansetron for prevention of post-operative nausea vomiting in patients undergoing laparoscopic gynaecological surgery

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dc.contributor.authorSharma, Shailendra Kumaren_US
dc.contributor.authorSingh, Shalendraen_US
dc.contributor.authorPaul, Debashishen_US
dc.contributor.authorAmeta, Niharen_US
dc.contributor.authorTaank, Priyaen_US
dc.contributor.authorSingh, Tinaen_US
dc.date.accessioned2020-11-18T10:00:58Z
dc.date.available2020-11-18T10:00:58Z
dc.date.issued2020-04
dc.description.abstractBackground: Post-operative nausea and vomiting (PONV) is generally self-limiting, associated with high level of patient dissatisfaction and may delay hospital discharge. The anaesthetist is usually blamed, despite evidence that PONV results from a variety of factors and variety of antiemetic drug available in market. With this issue we aim to compare the effectiveness of dexamethasone with granisetron or ondansetron in patients undergoing laparoscopic gynaecological surgery.Methods: 120 patients were registered in this prospective, randomized double blind study. Group I (n=60) received ondansetron 4 mg intravenously (IV)+dexamethasone 8mg I/V or II (n=60) received granisetron 1 mg IV+dexamethasone 8 mg I/V prior to anaesthesia. Post-operative data of PONV was recorded at pre-defined intervals.Results: The majority of the patients were of the age group 20-25 years (55.83%). The mean score of Group I subjects was 0.30±0.72 and that of Group II was 0.20±0.57 (p=0.43).  There are 3.33% of patients in group-I having vomiting episodes, and 1.67% of patients in group-II having vomiting episodes, none of the patients developed 2nd episodes of vomiting in either group. Thus it appears that dexamethasone in combination with ondansetron and granisetron is effective in decreasing the number of episodes of PONV. The occurrence of sickness episodes within 24 hours of surgery revealed no significant different in both groups. Haemodynamic variables showed no significant difference recorded in postoperative care unit between the study groups. The most common complaint was headache 16.67% in both groups.  Conclusions: Dexamethasone 8 mg with either granisetron 1 mg or ondansetron 4 mg showed no significant difference in antiemetic efficacy with minimal side effects and excellent patient satisfaction.en_US
dc.identifier.affiliationsDepartment of Anaesthesiology and Critical Care, Military Hospital, Bhopal, Madhya Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Anaesthesiology and Critical Care, Armed Forces Medical College Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Anaesthesiology and Critical Care, 160 Military Hospital, Masimpur, Assam, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, Command Hospital (Southern Command) Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynaecology, INHS Asvini, Mumbai, Maharashtra, Indiaen_US
dc.identifier.citationSharma Shailendra Kumar, Singh Shalendra, Paul Debashish, Ameta Nihar, Taank Priya, Singh Tina. Effect of dexamethasone with granisetron or ondansetron for prevention of post-operative nausea vomiting in patients undergoing laparoscopic gynaecological surgery. International Journal of Research in Medical Sciences. 2020 Apr; 8(4): 1331-1335en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/212096
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20201319en_US
dc.subjectGeneral anaesthesiaen_US
dc.subjectLaproscopic surgeryen_US
dc.subjectPost-operative nausea vomitingen_US
dc.titleEffect of dexamethasone with granisetron or ondansetron for prevention of post-operative nausea vomiting in patients undergoing laparoscopic gynaecological surgeryen_US
dc.typeJournal Articleen_US
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