Capillary versus Serum b-hydroxybutyrate in Pediatric Diabetic Ketoacidosis

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dc.contributor.authorKurup, Praveen Men_US
dc.contributor.authorchandran, Ramaen_US
dc.contributor.authorkumar, Rameshen_US
dc.contributor.authorSoundravally, Rajendranen_US
dc.contributor.authorSatheesh, Ponnarmenien_US
dc.date.accessioned2020-04-23T07:43:53Z
dc.date.available2020-04-23T07:43:53Z
dc.date.issued2019-02
dc.description.abstractObjective:To find the strength of agreement between point-of-care and serum β-hydroxybutyrate. Methods: 236 paired samples (capillary β-hydroxybutyrate by a point ofcare device and serum β-hydroxybutyrate by colorimetric enzymatic estimation) sampleswere collected from 26 children aged <13 years admitted with diabetic ketoacidosis. Inbornerrors of metabolism and septic shock were excluded. Results: Capillary β-hydroxybutyrateshowed excellent agreement with serum â-hydroxybutyrate with mean (SD) bias of 0.027(0.78); 95% limit of agreement -1.51, 1.56 and intraclass correlation 96.1% (95%CI 95%–97%, P<0.001). An increase in the bias noted for value above 5 mmol/L (P<0.001) (serummeasurements were higher than capillary point-of-care measure-ments). Capillary â-hydroxybutyrate correlated significantly with blood pH, anion gap,bicarbonate and carbondioxide levels on blood gas analysis (P<0.05). Conclusions: Capillary β-hydroxybutyrateestimation is a valid method for monitoring of ketonemia in pediatric diabetic ketoacidosisen_US
dc.identifier.affiliationsDepartments of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER), Puducherry, Indiaen_US
dc.identifier.affiliationsBiochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER), Puducherry, India.en_US
dc.identifier.citationKurup Praveen M, chandran Rama, kumar Ramesh, Soundravally Rajendran, Satheesh Ponnarmeni . Capillary versus Serum b-hydroxybutyrate in Pediatric Diabetic Ketoacidosis. Indian Pediatrics. 2019 Feb; 56(2): 126-129en_US
dc.identifier.issn0974-7559
dc.identifier.issn0019-6061
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199267
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber2en_US
dc.relation.volume56en_US
dc.source.urihttps://www.indianpediatrics.net/feb2019/126.pdfen_US
dc.subjectDiagnosisen_US
dc.subjectKetonemiaen_US
dc.subjectPoint-of-careen_US
dc.subjectType-I diabetes mellitusen_US
dc.titleCapillary versus Serum b-hydroxybutyrate in Pediatric Diabetic Ketoacidosisen_US
dc.typeJournal Articleen_US
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