Catecholamine-induced experimental cardiomyopathy--a histopathological, histochemical and ultrastructural study.

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dc.contributor.authorKhullar, Men_US
dc.contributor.authorDatta, B Nen_US
dc.contributor.authorWahi, P Len_US
dc.contributor.authorChakravarti, R Nen_US
dc.date.accessioned1989-09-01en_US
dc.date.accessioned2009-05-27T04:29:51Z
dc.date.available1989-09-01en_US
dc.date.available2009-05-27T04:29:51Z
dc.date.issued1989-09-01en_US
dc.description.abstractAn experimental model of myocardiopathy was induced in rhesus monkeys following noradrenaline (NA) infusion (20 ug/kg body wt/minute), for a period of 2 hours daily for three consecutive days. The animals were sacrificed after two hours (acute phase), forty-eight hours (sub-acute phase) and twenty-one days (chronic phase). Focal depletion of succinic dehydrogenase, increase in adenosine triphosphatase, acid phosphatase and appearance of large fat droplets in myocardial muscle was noted in the acute phase. Histopathological examination revealed focal edema, opacity and fuchsinorrhagia of the muscle fibres distributed in both the ventricles. Myofibrillar degeneration, myocytolysis and vacuolization with aggregation of lymphomononuclear cells were the significant features in the acute phase. During sub-acute and chronic phases, these features became less prominent and reparative changes with proliferation of fibroblasts became more marked. By the twenty-first day, irregular, focal scars replaced the necrosed myocardium. Ultrastructurally, heart muscle showed myofibrillar disorganisation, distortion of Z and A bands, dilatation of sarcoplasmic reticulum and swelling and rupture of mitochondria. Altered membrane permeability was evidenced by the presence of reaction products of horseradish peroxidase within the cardiac cells. In the reparative phase, however, myocytolytic changes regressed and collagen deposition was the prominent feature. This experimental study has several histological features simulating human cases of myocardial infarction without coronary occlusion.en_US
dc.identifier.citationKhullar M, Datta BN, Wahi PL, Chakravarti RN. Catecholamine-induced experimental cardiomyopathy--a histopathological, histochemical and ultrastructural study. Indian Heart Journal. 1989 Sep-Oct; 41(5): 307-13en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/5937
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCardiomyopathies --chemically induceden_US
dc.subject.meshHistocytochemistryen_US
dc.subject.meshMacaca mulattaen_US
dc.subject.meshMaleen_US
dc.subject.meshMitochondria, Heart --ultrastructureen_US
dc.subject.meshMyocardium --ultrastructureen_US
dc.subject.meshNecrosisen_US
dc.subject.meshNorepinephrineen_US
dc.titleCatecholamine-induced experimental cardiomyopathy--a histopathological, histochemical and ultrastructural study.en_US
dc.typeJournal Articleen_US
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