Inhibitors of factor VIII: detection and treatment.

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dc.contributor.authorBrettler, D Ben_US
dc.date.accessioned2009-05-27T16:19:06Z
dc.date.available2009-05-27T16:19:06Z
dc.date.issued1993-03-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health. 33 references.en_US
dc.description.abstractAlloantibodies occurring in hemophiliacs is a side effect or repeated treatment and represents a severe complication. The induction of immune tolerance using one of the lower dose regimens should be attempted as soon as it is feasible as regimens started soon after the inhibitor appears may have greater success in inducing tolerance. If the hemophiliac with inhibitor hemorrhages, PCC for aPCC should be the first line of therapy since these concentrates can be given in the home setting. If the hemorrhage is severe and the anti-porcine inhibitor titer is low, the patient should be infused in a clinic or hospital setting with porcine factor VIII using increasing doses to achieve a circulating factor VIII level. Entry into clinical trials, such as those using rFVIIa should be encouraged.en_US
dc.description.affiliationUniversity of Massachusetts Medical School, Worcester 01605.en_US
dc.identifier.citationBrettler DB. Inhibitors of factor VIII: detection and treatment. The Southeast Asian Journal of Tropical Medicine and Public Health. 1993 ; 24 Suppl 1(): 21-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/34932
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshBlood Coagulation Factors --therapeutic useen_US
dc.subject.meshFactor VIII --antagonists & inhibitorsen_US
dc.subject.meshHemophilia A --immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmune Tolerance --immunologyen_US
dc.subject.meshIsoantibodies --blooden_US
dc.titleInhibitors of factor VIII: detection and treatment.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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