The use of aripiprazole as an alternative medication to methylphenidate for treatment of attention-deficit/hyperactivity disorder

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dc.contributor.authorWarawat Chaichanen_US
dc.contributor.authorMantana Kittipeerachonen_US
dc.date.accessioned2011-02-20T04:34:05Z
dc.date.available2011-02-20T04:34:05Z
dc.date.created2011-01-24en_US
dc.date.issued2011-01-24en_US
dc.description.abstractObjective  To evaluate efficacy and adverse events of  the use of aripiprazole for treatment of pediatric patients with attention-deficit/hyperactivity disorder (ADHD).Materials and methods  Pediatric patients, ages 6-15 years, with ADHD who visited  Nakhonsawan Rajanakarindra Psychiatric Hospital during January to July 2010, and had received methylphenidate or had not received any treatment volunteered to receive an alternative medication, aripiprazole, for a period of 10 weeks. Outcomes were evaluated by using the Swanson, Nolan and Pelham version IV (SNAP-IV),  Clinical Global Impression – Severity scale (CGI-Severity), and Continuous Performance Test (CPT).  Statistical analysis was performed using descriptive statistics and Friedman test.Results  The sample included a total of 29 pediatric patients with ADHD. There were 17 patients who did not receive any treatment at the baseline. Results showed a significantly decrease from baseline in their ADHD symptoms, both inattentive symptoms and hyperactive/impulsivity symptoms, when receiving aripiprazole. There were 12 patients who used to  received methylphenidate before the study. No difference from baseline in their ADHD symptoms were seen when receiving aripiprazole. The commonly observed adverse event was weight gain, and no serious adverse event was observed.Conclusion  Aripiprazole reduced ADHD symptoms in pediatric patients, and can be used as an alternative medication to methylphenidate for controlling their symptoms during 10 weeks without any serious adverse events.  However, due to a number of limitations, further studies are warranted to confirm.Key words  :  alternative medication, aripiprazole, attention-deficit/hyperactivity disorder*Nakhonsawan  Rajanakarindra  Psychiatric  Hospital en_US
dc.identifier.citationJournal of Mental Health of Thailand - วารสารสุขภาพจิต แห่งประเทศไทย; Volume 19 Number 1 January 2011; 1-16en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/130952
dc.language.isoen_USen_US
dc.publisherJournal of Mental Health of Thailand - วารสารสุขภาพจิต แห่งประเทศไทยen_US
dc.rightsJournal of Mental Health of Thailand - วารสารสุขภาพจิต แห่งประเทศไทยen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/JMHT/issue/archiveen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/JMHT/article/view/4664en_US
dc.titleThe use of aripiprazole as an alternative medication to methylphenidate for treatment of attention-deficit/hyperactivity disorderen_US
dc.typeOriginal articlesen_US
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