Poor Respiratory Health Following Relapsing SARS-CoV-2 Infection in Children with Cystic Fibrosis

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dc.contributor.authorDhochak, Nitinen_US
dc.contributor.authorJat, Kana Ramen_US
dc.contributor.authorSoni, Kapil Deven_US
dc.contributor.authorSingh, Yudhyaviren_US
dc.contributor.authorAggarwa, Richaen_US
dc.contributor.authorLodha, Rakeshen_US
dc.contributor.authorTrikha, Anjanen_US
dc.contributor.authorKabra, Sushil K.en_US
dc.date.accessioned2023-08-19T04:53:34Z
dc.date.available2023-08-19T04:53:34Z
dc.date.issued2022-04
dc.description.abstractChildren with cystic fbrosis (CF) constitute a high-risk group for COVID-19 with underlying chronic lung disease. COVID19 severity varying from mild infection to need of intensive care has been described in children with CF. Two children with signifcant underlying pulmonary morbidity are described here, who developed severe disease following SARS-CoV-2 infection. Case 1 (a 9-y-old boy) had pneumonia with respiratory failure requiring noninvasive ventilation support. He had delayed clearance of SARS-CoV-2, with recurrence of symptomatic disease with short asymptomatic period in between. He was also diagnosed with CF-related diabetes and allergic bronchopulmonary aspergillosis during the second episode. Case 2 (an 18-mo-old boy) had two episodes of SARS-CoV-2–related severe lower respiratory infection within a period of 2 mo, requiring high-fow nasal oxygen support. Both children had 3rd pulmonary exacerbation but SARS-CoV-2 was not detected in respiratory secretions. To conclude, children with CF with underlying pulmonary morbidity, can develop severe COVID-19 and prolonged SARS-CoV-2 shedding.en_US
dc.identifier.affiliationsDepartment of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, Indiaen_US
dc.identifier.affiliationsDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.citationDhochak Nitin, Jat Kana Ram, Soni Kapil Dev, Singh Yudhyavir, Aggarwa Richa, Lodha Rakesh, Trikha Anjan, Kabra Sushil K.. Poor Respiratory Health Following Relapsing SARS-CoV-2 Infection in Children with Cystic Fibrosis. Indian Journal of Pediatrics. 2022 Apr; 89(4): 404–406en_US
dc.identifier.issn0973-7693
dc.identifier.issn0019-5456
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223712
dc.languageenen_US
dc.publisherDr. K C Chaudhuri Foundationen_US
dc.relation.issuenumber4en_US
dc.relation.volume89en_US
dc.source.urihttps://doi.org/10.1007/s12098-021-04057-0en_US
dc.subjectCystic fibrosisen_US
dc.subjectSARS-CoV-2en_US
dc.subjectPoor lung healthen_US
dc.subjectProlonged viral sheddingen_US
dc.titlePoor Respiratory Health Following Relapsing SARS-CoV-2 Infection in Children with Cystic Fibrosisen_US
dc.typeJournal Articleen_US
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