Association of IL-4 and IL-1RN (receptor antagonist) gene variants and the risk of type 2 diabetes mellitus: A study in the north Indian population.
dc.contributor.author | Bid, Hemant Kumar | en_US |
dc.contributor.author | Konwar, Rituraj | en_US |
dc.contributor.author | Agrawal, C G | en_US |
dc.contributor.author | Banerjee, Monisha | en_US |
dc.date.accessioned | 2008-07-09 | en_US |
dc.date.accessioned | 2009-05-29T05:57:12Z | |
dc.date.available | 2008-07-09 | en_US |
dc.date.available | 2009-05-29T05:57:12Z | |
dc.date.issued | 2008-07-09 | en_US |
dc.description.abstract | Background: Inflammation is a key event closely associated with the pathophysiology of type 2 diabetes mellitus (T2DM). Association of genetic polymorphisms of inflammatory cytokines with T2DM is largely unknown. Our objective was to investigate the relationship of polymorphism of IL-1RN and IL-4, two important biomarkers of inflammation, with the risk of T2DM. Setting and Design: We recruited 120 clinically diagnosed T2DM patients and 150 normal healthy controls for this study in order to evaluate the nature of polymorphisms of IL-1RN and IL-4. Materials and Methods: Genomic DNA was isolated from the blood of all subjects, and the variable number of tandem repeat (VNTR) polymorphisms of IL-1RN and IL-4 genes was identified by polymerase chain reaction. Statistical Analysis Used: Genotype distribution and allelic frequencies were compared between patients and control group. Means, as well as odds ratios (ORs) with 95% confidence intervals (CI), were calculated using SPSS software (version 11.5). Results: Our study revealed that distribution of both IL-4 and IL-1RN (VNTR) gene polymorphisms were significantly associated with T2DM subjects. We, however, failed to find any association of gene-gene (IL-4 and IL-1RN) interaction with T2DM. Conclusions: Both IL-4 and IL-1RN (VNTR) gene polymorphisms were significantly associated with T2DM subjects. This may suggest that the genetic polymorphisms of IL-4 and IL-1RN genes could serve as susceptibility indicators for T2DM in the Indian population, but the actual mechanism of these associations will require more elaborate investigations. Lack of association of gene-gene (IL-4 and IL-1RN) interaction with T2DM may indicate the independent nature of influence of both these genes on the risk of T2DM. | en_US |
dc.description.affiliation | Department of Zoology, University of Lucknow, Lucknow, India. banerjee_monisha@rediffmail.com. | en_US |
dc.identifier.citation | Bid HK, Konwar R, Agrawal CG, Banerjee M. Association of IL-4 and IL-1RN (receptor antagonist) gene variants and the risk of type 2 diabetes mellitus: A study in the north Indian population. Indian Journal of Medical Sciences. 2008 Jul; 62(7): 259-66 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/68249 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.indianjmedsci.org | en_US |
dc.title | Association of IL-4 and IL-1RN (receptor antagonist) gene variants and the risk of type 2 diabetes mellitus: A study in the north Indian population. | en_US |
dc.type | Journal Article | en_US |
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