Ocular manifestations in moderate-to-severe psoriasis in India: A prospective observational study

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dc.contributor.authorKharolia, Anjalien_US
dc.contributor.authorParija, Suchetaen_US
dc.contributor.authorMoharana, Bruttenduen_US
dc.contributor.authorSirka, Chandra Sekharen_US
dc.contributor.authorSahu, Sandip Kumaren_US
dc.date.accessioned2023-08-25T06:34:28Z
dc.date.available2023-08-25T06:34:28Z
dc.date.issued2022-09
dc.description.abstractPurpose: Ocular manifestations in psoriasis are due to direct eye involvement with psoriatic plaques or psoriasis?related, immune?mediated inflammatory processes. The commonly reported pathologies are blepharitis, conjunctivitis, keratitis, dry eyes, and uveitis. Limited data is available on the ocular findings in psoriasis patients in India. In this study, we evaluated various ocular changes associated with moderate-to-severe psoriasis. Methods: In this prospective cohort study, treatment?naive psoriasis patients with Psoriasis Area Severity Index (PASI) score of more than 10 were included. The Ocular Surface Disease Index (OSDI) score, Schirmer’s score, tear film breakup time (TBUT), corneal and conjunctival staining score, and meibomian gland dysfunction score were noted. All these parameters were re?evaluated at 8 weeks of follow?up after systemic treatment. Results: Sixty-eight patients were enrolled in the study. The most common ocular pathologies observed in this study were tarsal hyperemia and anterior blepharitis in 128 (94.1%) and 64 (47%) eyes, respectively. Mild, moderate, and severe dry eyes were seen in 26 (19.1%), 14 (10.2%), and 34 (25%) eyes, respectively. Thirty?nine (57.3%) patients complained of significant difficulty watching television or digital screen. In 21 patients evaluated on follow?up at 8 weeks, cornea and conjunctiva’s ocular surface staining score increased and TBUT decreased significantly. Conclusion: The most common ocular pathologies observed in this study were anterior blepharitis and moderate dry eye, which significantly affected most patients’ daily routines. Screening patients with greater severity of psoriasis would help in early management of such problems.en_US
dc.identifier.affiliationsDepartment of Ophthalmology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Dermatology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.citationKharolia Anjali, Parija Sucheta, Moharana Bruttendu, Sirka Chandra Sekhar, Sahu Sandip Kumar. Ocular manifestations in moderate-to-severe psoriasis in India: A prospective observational study. Indian Journal of Ophthalmology. 2022 Sep; 70(9): 3328-3332en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224574
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber9en_US
dc.relation.volume70en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_551_22en_US
dc.subjectDry Eyesen_US
dc.subjectocular manifestationen_US
dc.subjectpsoriasisen_US
dc.subjectSchirmer’sen_US
dc.subjecttear film breakup timeen_US
dc.titleOcular manifestations in moderate-to-severe psoriasis in India: A prospective observational studyen_US
dc.typeJournal Articleen_US
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