Mefloquine sulfadoxine pyrimethamine (MSP) combination delays in vitro emergence of mefloquine resistance in multiple drug resistant Plasmodium falciparum.

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dc.contributor.authorBrockelman, C Ren_US
dc.contributor.authorThanomsub, Ben_US
dc.contributor.authorBhisutthibhand, Jen_US
dc.date.accessioned2009-05-27T16:52:23Z
dc.date.available2009-05-27T16:52:23Z
dc.date.issued1989-09-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractSulfadoxine-pyrimethamine-resistant and chloroquine resistant, but mefloquine sensitive (MIC 5 x 10(-9] isolates of Plasmodium falciparum were used to study the emergence of mefloquine resistance. The continuously cultured isolates which were exposed intermittantly to varying concentrations of mefloquine alone became insensitive to the drug at 1 x 10(-7) M after 12 months, whereas the culture line exposed to the combination of mefloquine, sulfadoxine and pyrimethamine became only slightly insensitive to mefloquine (MIC 2 x 10(-8]. Thus, the efficacy of mefloquine may be prolonged through use in combination with sulfadoxine-pyrimethamine.en_US
dc.description.affiliationDepartment of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationBrockelman CR, Thanomsub B, Bhisutthibhand J. Mefloquine sulfadoxine pyrimethamine (MSP) combination delays in vitro emergence of mefloquine resistance in multiple drug resistant Plasmodium falciparum. The Southeast Asian Journal of Tropical Medicine and Public Health. 1989 Sep; 20(3): 371-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36202
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshHumansen_US
dc.subject.meshMefloquine --therapeutic useen_US
dc.subject.meshParasitology --methodsen_US
dc.subject.meshPlasmodium falciparum --drug effectsen_US
dc.subject.meshPyrimethamine --therapeutic useen_US
dc.subject.meshSulfadoxine --therapeutic useen_US
dc.subject.meshSulfanilamides --therapeutic useen_US
dc.subject.meshThailanden_US
dc.subject.meshTime Factorsen_US
dc.titleMefloquine sulfadoxine pyrimethamine (MSP) combination delays in vitro emergence of mefloquine resistance in multiple drug resistant Plasmodium falciparum.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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