Revisiting the Efficacy of Immunomodulatory Effect of Hydroxychloroquine in Oral Lichen Planus: A Case Series

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dc.contributor.authorDayanandam, Malaen_US
dc.contributor.authorPushpanjalien_US
dc.contributor.authorPasupuleti, Pravallikaen_US
dc.contributor.authorSatya, Neeharikaen_US
dc.contributor.authorJyothi, Seelam Divyaen_US
dc.contributor.authorSree, M. Satyaen_US
dc.date.accessioned2019-12-02T09:49:01Z
dc.date.available2019-12-02T09:49:01Z
dc.date.issued2017-11
dc.description.abstractOral lichen planus (OLP) is a common inflammatory, autoimmune disorder that affects stratified squamous epithelium. The exact etiopathogenesis of this mucocutaneous disease is still uncertain. Although OLP has been associated with altered Quality of Life and considerable morbidity, with important note for erosive type of OLP, its treatment is often disappointing and controversial. Though corticosteroids remained the first line of treatment for OLP, the associated adverse effects of corticosteroids are not acceptable. Hence, there is a need of drugs with steroid sparing effect. Use of immunomodulators is systemic pathologies is widely encountered. However, their use in oral lesions is not frequently seen. Use of hydroxychloroquine (HCQ), an age-old disease-modifyinganti-rheumatic-drug, has been widely used in various autoimmune diseases; however, it received little attention in treatment of OLP. This article presents a case series of three patients with erosive OLP which were managed with HCQ. The results presented allow the authors to consider systemic HCQ as a newer therapy for atrophicerosive lichen planus.en_US
dc.identifier.affiliationsAssistant Professor, Department of Oral Medicine and Radiology, Government Dental College and Hospital, RIMS, Kadapa, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Department of Oral and Maxillofacial Surgery, Government Dental College and Hospital, RIMS, Kadapa, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsPost Graduate Department of Oral Medicine and Radiology, Government Dental College and Hospital, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsSenior Resident; Department of Oral Medicine and Radiology, Government Dental College and Hospital, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsPost Graduate Department of Oral Medicine and Radiology, Government Dental College and Hospital, Hyderabad, Telangana, Indiaen_US
dc.identifier.citationDayanandam Mala, Pushpanjali, Pasupuleti Pravallika, Satya Neeharika, Jyothi Seelam Divya, Sree M. Satya. Revisiting the Efficacy of Immunomodulatory Effect of Hydroxychloroquine in Oral Lichen Planus: A Case Series. Indian Journal of Mednodent and Allied Sciences. 2017 Nov; 5(3): 219-223en_US
dc.identifier.issn2347-6192
dc.identifier.issn2347-6206
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/186086
dc.languageenen_US
dc.publisherAssociation of Medical Dental and Allied Sciencesen_US
dc.relation.issuenumber3en_US
dc.relation.volume5en_US
dc.source.urihttps://dx.doi.org/10.5958/2347-6206.2017.00036.Xen_US
dc.subjectCell-mediated immunityen_US
dc.subjectHydroxychloroquineen_US
dc.subjectImmunomodulatorsen_US
dc.subjectMucocutaneous disordersen_US
dc.subjectPotentially malignant disordersen_US
dc.subjectTlymphocytesen_US
dc.titleRevisiting the Efficacy of Immunomodulatory Effect of Hydroxychloroquine in Oral Lichen Planus: A Case Seriesen_US
dc.typeJournal Articleen_US
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