Ultrasonographic Discrimination of Benign and Malignant Breast Lumps with Histopathological Correlation.
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Date
2015-09
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Abstract
Background: A lump in the breast is a cause of great concern. High frequency high resolution
ultrasonogram helps in its evaluation. With major advances in ultrasonographic technology during
the past 20 years, ultrasonogram can now distinguish benign and malignant solid breast lumps.
Knowledge of the specific benign and malignant ultrasonographic characteristics of breast lumps
is imperative for accurate diagnosis and optimal patient management. Objective: To determine the
validity of ultrasound in the assessment of palpable breast lump by detecting the sensitivity,
specificity, accuracy, positive predictive value and negative predictive value of ultrasonogram in
distinguishing benign and malignant breast lumps. Materials and Methods: This cross sectional
study was done in the department of Radiology and Imaging of Bangabandhu Sheikh Mujib
Medical University (BSMMU), Dhaka in collaboration with the department of Pathology of
BSMMU for histopathological correlation during July 2008 to June 2009. A total of 100 patients
who were clinically suspected of having breast lump were included in this study. Data on clinical
presentation, ultrasonographic findings including histopathological reports were collected and
documented in structured forms. Analysis was done using SPSS 13.0 version. Results: The study
was done in 100 women of 18–70 years of age with mean age 41.46 ± 11.62 years. Breast lumps
were found with associated clinical presentation of pain in 26 (26%) cases, discharge in 12 (12%)
cases, skin changes in 28 (28%) cases, nipple retraction in 10 (10%) cases, and palpable lymph
nodes in 10 (10%) cases. On ultrasonogram, lesions were diagnosed as benign in 62% cases and
malignant in 38% cases. Out of sonographically diagnosed 62 benign lesions 58 (93.5%) were
also proved benign histopathologically and 4 (6.5%) as malignant. Out of 38 sonographically
malignant lesions, 34 (89.5%) were also proved as malignant histopathologically and 4 (10.5%) as
benign. Conclusion: Ultrasonographic findings of benign and malignant breast lumps correlated
well in most of the cases with the histopathological results. Therefore, it can be concluded that
ultrasonogram is a useful imaging tool to discriminate benign and malignant breast lumps and
thus we can reduce unnecessary breast biopsies, patient discomfort and anxiety in addition to
increase in cost of the patient.
Description
Keywords
Benign, Malignant, Palpable breast lumps, Ultrasonogram
Citation
Yasmin Tarana, Sultana Sohely, Amin Mashah Binte, Arephen Syed Shamsul, Rafat Sania, Farzana Tayseer. Ultrasonographic Discrimination of Benign and Malignant Breast Lumps with Histopathological Correlation. Journal of Enam Medical College. 2015 Sept; 5(3): 151-156.