Spectrum of Reactive Morphological Alterations in Leucocytes in HIV Patients.

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dc.contributor.authorSrivastav, Sen_US
dc.contributor.authorMardi, Ken_US
dc.contributor.authorPrasad, V.en_US
dc.date.accessioned2023-07-14T06:58:55Z
dc.date.available2023-07-14T06:58:55Z
dc.date.issued2022-03
dc.description.abstractBackground: The earliest hematological manifestation of HIV infection can occur at the time of primary infection. Several peripheral blood abnormalities are known in HIV. However, not many studies have reported morphological changes in white blood cells in antiviral naïve patients and even fewer have compared them with HIV seropositive patients. Material and methods: Peripheral blood smears from 100 patients were studied. 50 of them were newly diagnosed HIV seropositive cases and 50 were HIV seronegative. A peripheral blood smear was made to study morphology of various white blood cells A written informed consent was taken. Statistical analysis of the data obtained was done. Results: Morphological abnormalities in the lymphocytes had been the most significant finding, which included nuclear lobulation, nuclear convolution and plasmacytoid and monocytoid features. Neutrophils also showed various morphological abnormalities. Most common were hypogranulation, hypersegmented nuclei and cytoplasmic vacuolations in descending order of frequency. Monocytes also revealed few morphological abnormalities including nuclear irregularities and cytoplasmic vacuolations. Conclusion: The observations from this study will serve as a guide to clinicians as treatment of these patients should include supplements to monitor and improve these changes.en_US
dc.identifier.affiliationsDept. of Pathology, Veer Chandra Singh Garhwali Government Institute of Medical Sciences and Research, Srinagaren_US
dc.identifier.affiliationsDept. of Pathology, Indira Gandhi Medical college, Shimlaen_US
dc.identifier.affiliationsDept. of Anaesthesia, Veer Chandra Singh Garhwali Government Institute of Medical Sciences and Research, Srinagar.en_US
dc.identifier.citationSrivastav S, Mardi K, Prasad V.. Spectrum of Reactive Morphological Alterations in Leucocytes in HIV Patients.. Light House Polyclinic. 2022 Mar; 21(1): 1-4en_US
dc.identifier.issn0972-5997
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/218349
dc.languageenen_US
dc.publisherLight House Polyclinicen_US
dc.relation.issuenumber1en_US
dc.relation.volume21en_US
dc.source.urihttps://www.ojhas.org/issue81/2022-1-7.pdfen_US
dc.subjectHIVen_US
dc.subjecthematologicalen_US
dc.subjectmorphologicalen_US
dc.subjectwhite blood cellsen_US
dc.titleSpectrum of Reactive Morphological Alterations in Leucocytes in HIV Patients.en_US
dc.typeJournal Articleen_US
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