Association of HLA-*08:DRB1*03 with immunoglobulin A-deficiency.

Simple item page
dc.contributor.authorCzyzewska-BuczyƱska, Agnieszkaen_US
dc.contributor.authorMajkowska-Skrobek, Grazynaen_US
dc.contributor.authorJankowski, Adamen_US
dc.date.accessioned2007-11-07en_US
dc.date.accessioned2009-05-30T11:12:13Z
dc.date.available2007-11-07en_US
dc.date.available2009-05-30T11:12:13Z
dc.date.issued2007-11-07en_US
dc.description.abstractOBJECTIVE: Susceptibility to IgA deficiency (IgAD) is strongly associated with alleles of HLA, but it is not equally strong in different human populations. Therefore, the goal of this study was to determine the HLA-A, -B and -DRB1 antigenic and haplotypic frequencies in unrelated Polish Caucasian IgA-deficient patients who had never been examined so far in this respect. METHODS: The HLA alleles were determined by means of low resolution polymerase chain reaction with sequence specific primers (PCR-SSP) method in a group of IgA-deficient patients and control subjects from the same area. RESULTS: The HLA-DRB1*03 allele showed the strongest association with IgA deficiency in the Polish population (OR=6.6, p cor=0.0084). The HLA-B*08 allele was also associated with predisposition to the disease (OR=6.22, p cor=0.033). These significant associations could be explained in the context of a positive association of IgAD with the HLA-B*08:DRB1*03 haplotype, previously reported in other Caucasoid populations from Northern and Central Europe. In our group the HLA-B*08:DRB1*03 haplotype was present in 52.9% of IgA-deficient patients comparing to 9.9% in controls (p< 0.00011). A positive association of HLA-B*08 and DRB1*03 was stronger in IgA-deficient males than in females from the same group. CONCLUSION: Immunoglobulin A deficiency in Polish population is strongly associated with HLA-B*08:DRB1*03 haplotype rather than with single alleles.en_US
dc.description.affiliationDepartment of Pediatric Propedeutics, Division of Children's Immunology and Rheumatology, Medical University of Wroclaw, Wroclaw, Poland. czyzewskaagnieszka@wp.plen_US
dc.identifier.citationCzyzewska-BuczyƱska A, Majkowska-Skrobek G, Jankowski A. Association of HLA-*08:DRB1*03 with immunoglobulin A-deficiency. Indian Journal of Pediatrics. 2007 Nov; 74(11): 1021-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/79434
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHLA-A Antigens --blooden_US
dc.subject.meshHLA-B Antigens --blooden_US
dc.subject.meshHLA-DR Antigens --blooden_US
dc.subject.meshHaplotypesen_US
dc.subject.meshHumansen_US
dc.subject.meshIgA Deficiency --immunologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPhenotypeen_US
dc.titleAssociation of HLA-*08:DRB1*03 with immunoglobulin A-deficiency.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Pediatrics