Molecular cloning and characterization of a novel human kinase gene, PDIK1L.

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dc.contributor.authorGuo, Lingchenen_US
dc.contributor.authorJi, Chaonengen_US
dc.contributor.authorGu, Shaohuaen_US
dc.contributor.authorYing, Kangen_US
dc.contributor.authorCheng, Haipengen_US
dc.contributor.authorNi, Xiaoghuaen_US
dc.contributor.authorLiu, Jianpingen_US
dc.contributor.authorXie, Yien_US
dc.contributor.authorMao, Yuminen_US
dc.date.accessioned2003-04-25en_US
dc.date.accessioned2009-06-02T07:23:44Z
dc.date.available2003-04-25en_US
dc.date.available2009-06-02T07:23:44Z
dc.date.issued2003-04-25en_US
dc.description.abstractWe isolated a 4301-bp cDNA from a human foetal brain cDNA library by high-throughput cDNA sequencing. It encodes a protein of 341 amino acids, which shows 69% identity with the human kinase CLIK1 (AAL99353), which was suggested to be the CLP-36 interacting kinase. Bioinformatics analysis suggests that the putative kinase may interact with PDZ and LIM domain proteins. Therefore the protein and its cDNA were named 'PDLIM1 interacting kinase 1 like' (PDIK1L; nomenclature approved by the HUGO Gene Nomenclature Committee). Ensembl Genome Browser located PDIK1L to human chromosome 1p35.3. It spans about 13.7 kb and consists of four exons and three introns. Multiple-tissue cDNA panel PCR revealed that the gene is expressed widely in human tissues: liver, kidney, pancreas, spleen, thymus and prostate. The protein appears to be localized to the nucleus.en_US
dc.description.affiliationState Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, People's Republic of China.en_US
dc.identifier.citationGuo L, Ji C, Gu S, Ying K, Cheng H, Ni X, Liu J, Xie Y, Mao Y. Molecular cloning and characterization of a novel human kinase gene, PDIK1L. Journal of Genetics. 2003 Apr-Aug; 82(1-2): 27-32en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/114424
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jgenet/index.htmlen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshBrain --physiologyen_US
dc.subject.meshCloning, Molecularen_US
dc.subject.meshDNA, Complementaryen_US
dc.subject.meshDNA-Binding Proteins --geneticsen_US
dc.subject.meshGene Expressionen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNerve Tissue Proteins --geneticsen_US
dc.subject.meshNuclear Proteinsen_US
dc.subject.meshPhosphotransferases --geneticsen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshProtein Kinasesen_US
dc.subject.meshProtein-Serine-Threonine Kinases --geneticsen_US
dc.subject.meshSequence Homology, Amino Aciden_US
dc.subject.meshSubcellular Fractionsen_US
dc.subject.meshTissue Distributionen_US
dc.subject.meshTranscription Factorsen_US
dc.titleMolecular cloning and characterization of a novel human kinase gene, PDIK1L.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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