Carotid artery occlusion causes reversible brain damage in rat.

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dc.contributor.authorAftabuddin, Men_US
dc.contributor.authorIslam, Nen_US
dc.contributor.authorMoriwaki, Aen_US
dc.contributor.authorHori, Yen_US
dc.date.accessioned1994-05-01en_US
dc.date.accessioned2009-05-27T04:27:00Z
dc.date.available1994-05-01en_US
dc.date.available2009-05-27T04:27:00Z
dc.date.issued1994-05-01en_US
dc.description.abstractIn order to assess the density and distribution of brain damage after pure focal ischemia uncomplicated by hypotension or hypoxia, ischemia was produced by occlusion of one and/or both common carotid arteries (CCA) temporarily or permanently in the rat, followed by 3 months recovery. The brains were perfusion-fixed with formaldehyde, embedded in paraffin, subserially sectioned, and stained with hematoxylin-eosin/cresyl violet. Mild ipsilateral neuronal damage was observed after unilateral permanent occlusion, but confined only to the hippocampus. Damage of neocortical neurons began to appear after 1 day following bilateral permanent occlusion. Damage was worst over the superolateral convexity of both hemispheres, CA 4 and subiculur neurons; subsequently other sectors of hippocampus and other brain structures were affected. Some damaged neurons in the superficial cortex and CA 1 sector of hippocampus, and almost all in the other regions of brain reverted to normal profile by 3 months of recovery. All brain structures showed normal profiles, except a relative neuronal rarefication in neocortex and CA 1 sector of hippocampus after 3 months of recovery. These results suggests that only CCA occlusion causes partial/incomplete ischemia in the rat brain, where damaging effects are counterbalanced by metabolic and circulatory adjustments.en_US
dc.description.affiliationDepartment of Physiology and Pathology, Okayama University School, Japan.en_US
dc.identifier.citationAftabuddin M, Islam N, Moriwaki A, Hori Y. Carotid artery occlusion causes reversible brain damage in rat. Indian Heart Journal. 1994 May-Jun; 46(3): 171-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/5349
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain --pathologyen_US
dc.subject.meshBrain Ischemia --etiologyen_US
dc.subject.meshCarotid Artery, Commonen_US
dc.subject.meshCarotid Stenosis --complicationsen_US
dc.subject.meshElectroencephalographyen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshTime Factorsen_US
dc.titleCarotid artery occlusion causes reversible brain damage in rat.en_US
dc.typeJournal Articleen_US
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