Significant reduction of granulomas in Nrf2-deficientmice infected with Mycobacterium tuberculosis.
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Date
2010-04
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Abstract
Objective: We have reported previously that mice deficient in nuclear erythroid 2 p45-related factor 2 (Nrf2), which
regulates the expression of antioxidant and detoxification genes, showed significant susceptibility to airway inflammatory
responses when exposed to diesel exhaust particles for eight weeks2. As disruption of Nrf2 promotes immune cells that
stimulate Th2-like immunoresponsiveness, Nrf2-deficient mice may be resistant to M. tuberculosis infection.
Setting: Nrf2-deficient mice were infected with M. tuberculosis aerially, and the size of their granulomas and cytokine mRNA
expression were compared with those of wild-type mice.
Results: Significant reduction of granuloma formation and tubercle bacilli in granulomas was noted in the deficient mice 27
weeks after infection, concurrently with higher expression of IL-2 and IL-13 mRNA.
Conclusion: It is concluded that Nrf2 inversely regulates M. tuberculosis-induced granuloma development at the late stage.
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Keywords
Nrf2, C57BL/6 mouse, M. tuberculosis, Th2 cytokine
Citation
Mizuno S, Yamamoto M, Sugawara I. Significant reduction of granulomas in Nrf2-deficientmice infected with Mycobacterium tuberculosis. Indian Journal of Tuberculosis. 2010 Apr; 57(2): 108-113.