Comparison between efficacy of oral artemether 480mg and combination of oral artemether 480mg and mefloquine 1000mg in acute uncomplicated p. falciparum malaria

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dc.contributor.authorYe Thween_US
dc.contributor.authorYin Yin Tunen_US
dc.contributor.authorKyaw Soe Tunen_US
dc.contributor.authorKyaw Thet Tunen_US
dc.contributor.authorHtet Htet Nyunten_US
dc.contributor.authorMyat Myat Hanen_US
dc.contributor.authorAye Kyuen_US
dc.contributor.authorHla Yeeen_US
dc.contributor.authorSithu Aungen_US
dc.contributor.authorKhin Nien_US
dc.date.accessioned2009-06-13T13:42:26Z
dc.date.available2009-06-13T13:42:26Z
dc.date.created1994-01-01en_US
dc.date.issued1994-01-01en_US
dc.description.abstractA prospective study comparing the efficacy of Artemether capsule (160 mg. tat and 80 mg. 12 hourly for four doses with a total dose of 480 mg.) as a single drug regimen and a combination drug regimen of Artemether capsule 480 mg. as above together with oral Mefloquine two equal split doses (500 mg 6 hours apart) was carried out at the No. 2, Military Hospital, Yangon during January 1993 and September, 1993. 30 patients were included in oral Artemether single drug regimen and 35 patients were included in oral Artemether and Mefloquine combination drug regimen. The mean age of two groups were 25.82 years and 25.37 years respectively. The initial parasite counts were 13736 and 16879 per microlitre respectively. All patients cleared the parasites initially in both groups. However, 12 patients (40 percent) recrudesced as RI cases in Artemether single drug regimen and thus cure rate was 60 percent. In combination drug regimen group 2 patients (5. 71 percent) recrudesced and cure rate was 94.29 percent. The parasite clearance time (PCT), fever clearance time (FCT) and 50 percent reduction time were compared in both groups and the results were 44.85*** 19.01 hours, 26.56*** 14.14 hours, 40.25*** 16.76 hours, 23.77*** 18.69 hours and 14.28*** 10.11 hours, 12.94*** 6.86 hours respectively. Significant side effects were not noted among patients in both groups. This study showed that Artemether capsule and Mefloquine combination drug regimen has higher efficacy interms of PCT, FCT and 50 percent reduction time than Artemether capsule single drug regimen for patients with acute uncomplicated falciparum malaria in Myanmar.en_US
dc.identifier.citationYe Thwe, Yin Yin Tun, Kyaw Soe Tun, Kyaw Thet Tun, Htet Htet Nyunt, Myat Myat Han, Aye Kyu, Hla Yee, Sithu Aung, Khin Ni. Comparison between efficacy of oral artemether 480mg and combination of oral artemether 480mg and mefloquine 1000mg in acute uncomplicated p. falciparum malaria. Myanmar Medical Journal. 1994; 39(1): 137en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/126514
dc.subject.meshMefloquineen_US
dc.subject.meshMalaria, Falciparum-drug therapyen_US
dc.subject.meshMyanmaren_US
dc.titleComparison between efficacy of oral artemether 480mg and combination of oral artemether 480mg and mefloquine 1000mg in acute uncomplicated p. falciparum malariaen_US
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