In vitro antifilarial activity of Sencio nudicaulis Buch. Ham. Effect on Setaria cervi (Nematoda Filarioidea).

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dc.contributor.authorSingh, Ren_US
dc.contributor.authorKhan, N Uen_US
dc.contributor.authorSinghall, K Cen_US
dc.date.accessioned1996-07-01en_US
dc.date.accessioned2009-06-01T07:49:46Z
dc.date.available1996-07-01en_US
dc.date.available2009-06-01T07:49:46Z
dc.date.issued1996-07-01en_US
dc.description.abstractThe effect on aqueous and alcoholic extracts of the leaves of Sencio nudicaulis Buch. Ham. was studied on the spontaneous movements of the whole worm and nerve-muscle preparation of Setaria cervi and on the survival of micro-filariae in vitro. Aqueous as well as alcoholic extracts caused inhibition of spontaneous motility of the whole worm and nerve-muscle preparation of S. cervi characterized by decreased amplitude, rate and tone of contractions. The concentration required to inhibit the movements of n.m. preparation was 1/3rd for aqueous and 1/20th for alcoholic extract suggesting a cuticular permeability barrier. The effect of S nudicaulis extracts was different than that produced by calcium channel blocker nifedipine on the whole worm and n.m. preparation. While nifedipine blocks the stimulant effect of Ach the extracts of S. nudicaulis fails to do so. While the response bears similarity with DEC which also does not block Ach response. Both aqueous and alcoholic extracts exhibited microfilaricidal action in vitro LC50 and LC90 being 10 and 15 ng/ml for aqueous extract, 5 and 12 ng/ml for alcoholic extract.en_US
dc.description.affiliationDepartment of Pharmacology, J.N. Medical College, Aligarh Muslim University.en_US
dc.identifier.citationSingh R, Khan NU, Singhall KC. In vitro antifilarial activity of Sencio nudicaulis Buch. Ham. Effect on Setaria cervi (Nematoda Filarioidea). Indian Journal of Physiology and Pharmacology. 1996 Jul; 40(3): 231-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108454
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFilaricides --pharmacologyen_US
dc.subject.meshFilarioidea --drug effectsen_US
dc.subject.meshNeuromuscular Junction --drug effectsen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshPlants, Medicinalen_US
dc.titleIn vitro antifilarial activity of Sencio nudicaulis Buch. Ham. Effect on Setaria cervi (Nematoda Filarioidea).en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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