Role of Imprint Cytology in Diagnosis of Lymph Node Lesions.
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Date
2011-10
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Abstract
Introduction: Imprint cytology is proved to be rapid
inexpensive tool in the diagnosis of various lymph node
lesions. Objective: The present study was conducted to
correlate the diagnostic accuracy, sensitivity and specificity
of imprint cytology of various lymph node lesions with
histopathological diagnosis. 102 cases were included in the
study comprising inflammatory lesion, tubercular
lymphadenitis, lymphomas and metastatic carcinomas.
Material and Method: From 102 cases of lymph node
excision, imprint smears were taken and stained with
Hematoxylin & Eosin and Papanicolaou stains. The findings
of imprint cytology were then compared with final
histopathological diagnosis. Result: When compared with
final histopathological diagnosis, imprint smears showed
overall diagnostic accuracy of 97.8% with sensitivity and
specificity of 95.05% and 98.69% respectively. Accuracy
rate for metastatic lymphadenopathy was 100%, whereas,
for tubercular lymphadenitis it was 98.04% and for
lymphomas 96.04%. Conclusion: Imprint cytology proved
to be very useful for diagnosis of metastatic tumour as it
gave 100% diagnostic accuracy, sensitivity and specificity.
Imprint cytology is also considered to be useful in superficial
ulcers to differentiate between benign and malignant lesions
without surgical intervention.
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Keywords
imprint cytology, lymphnode lesions, lymphnode malignancies, lymphoma
Citation
Arif S H, Verma A K, Hassan Mohd Jaseem, Naim M, Jain Manu. Role of Imprint Cytology in Diagnosis of Lymph Node Lesions. Indian Medical Gazette. 2011 Oct ; 145 (10): 385-390.