Lipid peroxide, beta-carotene and alpha-tocopherol in ischaemic stroke and effect of exogenous vitamin E supplementation on outcome.
dc.contributor.author | Daga, M K | en_US |
dc.contributor.author | Madhuchhanda, | en_US |
dc.contributor.author | Mishra, T K | en_US |
dc.contributor.author | Mohan, A | en_US |
dc.date.accessioned | 1997-11-07 | en_US |
dc.date.accessioned | 2009-05-30T21:52:28Z | |
dc.date.available | 1997-11-07 | en_US |
dc.date.available | 2009-05-30T21:52:28Z | |
dc.date.issued | 1997-11-07 | en_US |
dc.description.abstract | 30 patients with CT proven infarct presenting within 24 hours of the acute event were included in the study with 20 age and sex matched controls. On day 1 and day 15 of stroke, levels of plasma lipid peroxide (oxidant) and plasma alpha-tocopherol and beta carotene (antioxidant) were estimated. The patients were randomly assigned to two groups, one group receiving 300 mg/day of vitamin E for 15 days. Neurological examination was conducted according to Mathew scale on day 1 and day 15 and rehabilitation assessment was done at day 15 and at 6 weeks according to Barthel Index. On day 1, the mean value of plasma lipid peroxidation in controls was 4.97 +/- 1.44 nmol/ml and in stroke patients 5.89 +/- 1.56 nmol/ml (p < 0.05). The plasma beta-carotene in controls was 2.35 +/- 1.09 mg/L while in stroke patients was 1.07 +/- 0.55 mg/L (p < 0.001) and plasma alpha-tocopherol in control 9.74 +/- 2.76 micrograms/ml as compared to 7.57 +/- 2.92 micrograms/ml in stroke patients (p < 0.02). Initially the plasma lipid peroxide levels are high and antioxidant levels are low in patients of ischemic stroke. Exogenous vitamin E supplementation does not have any significant effect on early neurological outcome but it does bring about significant changes in subsequent recovery and rehabilitation of patients of stroke. | en_US |
dc.description.affiliation | Department of Medicine and Biochemistry, Maulana Azad Medical College and Associated, Lok Nayak Hospital, New Delhi-110002. | en_US |
dc.identifier.citation | Daga MK, Madhuchhanda , Mishra TK, Mohan A. Lipid peroxide, beta-carotene and alpha-tocopherol in ischaemic stroke and effect of exogenous vitamin E supplementation on outcome. Journal of the Association of Physicians of India. 1997 Nov; 45(11): 843-6 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/89018 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.japi.org | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Lipid Peroxidation | en_US |
dc.subject.mesh | Lipid Peroxides --blood | en_US |
dc.subject.mesh | Stroke --blood | en_US |
dc.subject.mesh | Vitamin E --blood | en_US |
dc.subject.mesh | beta Carotene --blood | en_US |
dc.title | Lipid peroxide, beta-carotene and alpha-tocopherol in ischaemic stroke and effect of exogenous vitamin E supplementation on outcome. | en_US |
dc.type | Clinical Trial | en_US |
dc.type | Journal Article | en_US |
dc.type | Randomized Controlled Trial | en_US |
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