Lipid peroxide, beta-carotene and alpha-tocopherol in ischaemic stroke and effect of exogenous vitamin E supplementation on outcome.

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dc.contributor.authorDaga, M Ken_US
dc.contributor.authorMadhuchhanda,en_US
dc.contributor.authorMishra, T Ken_US
dc.contributor.authorMohan, Aen_US
dc.date.accessioned1997-11-07en_US
dc.date.accessioned2009-05-30T21:52:28Z
dc.date.available1997-11-07en_US
dc.date.available2009-05-30T21:52:28Z
dc.date.issued1997-11-07en_US
dc.description.abstract30 patients with CT proven infarct presenting within 24 hours of the acute event were included in the study with 20 age and sex matched controls. On day 1 and day 15 of stroke, levels of plasma lipid peroxide (oxidant) and plasma alpha-tocopherol and beta carotene (antioxidant) were estimated. The patients were randomly assigned to two groups, one group receiving 300 mg/day of vitamin E for 15 days. Neurological examination was conducted according to Mathew scale on day 1 and day 15 and rehabilitation assessment was done at day 15 and at 6 weeks according to Barthel Index. On day 1, the mean value of plasma lipid peroxidation in controls was 4.97 +/- 1.44 nmol/ml and in stroke patients 5.89 +/- 1.56 nmol/ml (p < 0.05). The plasma beta-carotene in controls was 2.35 +/- 1.09 mg/L while in stroke patients was 1.07 +/- 0.55 mg/L (p < 0.001) and plasma alpha-tocopherol in control 9.74 +/- 2.76 micrograms/ml as compared to 7.57 +/- 2.92 micrograms/ml in stroke patients (p < 0.02). Initially the plasma lipid peroxide levels are high and antioxidant levels are low in patients of ischemic stroke. Exogenous vitamin E supplementation does not have any significant effect on early neurological outcome but it does bring about significant changes in subsequent recovery and rehabilitation of patients of stroke.en_US
dc.description.affiliationDepartment of Medicine and Biochemistry, Maulana Azad Medical College and Associated, Lok Nayak Hospital, New Delhi-110002.en_US
dc.identifier.citationDaga MK, Madhuchhanda , Mishra TK, Mohan A. Lipid peroxide, beta-carotene and alpha-tocopherol in ischaemic stroke and effect of exogenous vitamin E supplementation on outcome. Journal of the Association of Physicians of India. 1997 Nov; 45(11): 843-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/89018
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshHumansen_US
dc.subject.meshLipid Peroxidationen_US
dc.subject.meshLipid Peroxides --blooden_US
dc.subject.meshStroke --blooden_US
dc.subject.meshVitamin E --blooden_US
dc.subject.meshbeta Carotene --blooden_US
dc.titleLipid peroxide, beta-carotene and alpha-tocopherol in ischaemic stroke and effect of exogenous vitamin E supplementation on outcome.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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