Comparing acromegalic patients to healthy controls with respect to intraocular pressure, central corneal thickness, and optic disc topography findings.

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dc.contributor.authorSen, Emine
dc.contributor.authorTutuncu, Yasemin
dc.contributor.authorElgin, Ufuk
dc.contributor.authorBalikoglu Yilmaz, Melike
dc.contributor.authorBerker, Dilek
dc.contributor.authorNur Aksakal, F
dc.contributor.authorOzturk, Faruk
dc.contributor.authorGuler, Serdar
dc.date.accessioned2015-02-03T05:01:36Z
dc.date.available2015-02-03T05:01:36Z
dc.date.issued2014-08
dc.description.abstractAims: The aim was to compare the intraocular pressure (IOP), central corneal thickness (CCT), and optic disc topography fi ndings of biochemically controlled acromegalic patients and the control group and to evaluate the eff ect of the duration of acromegaly and serum growth hormone and insulin-like growth factor-1 (IGF-1) levels on these ocular parameters. Materials and Methods: IOP measurement with Goldmann applanation tonometry, CCT measurement with ultrasonic pachymetry, and topographic analysis with Heidelberg retinal tomograph III were performed on 35 biochemically controlled acromegalic patients and 36 age- and gender-matched controls. Results: Mean IOP and CCT were 14.7 ± 2.9 mmHg and 559.5 ± 44.9 m in the acromegaly patients and 13.0 ± 1.6 mmHg and 547.1 ± 26.7 m in controls (P = 0.006 and P = 0.15, respectively). A signifi cant moderate correlation was found between the duration of acromegaly and CCT (r = 0.391) and IOP (r = 0.367). Mean retinal nerve fi ber layer (RNFL) thickness was signifi cantly lower in the acromegalic patients (0.25 ± 0.05 mm) as compared to controls (0.31 ± 0.09 mm) (P = 0.01). A signifi cant moderate correlation was detected between IGF-1 level and disc area (r = 0.362), cup area (r = 0.389) and cup volume (r = 0.491). Conclusion: Biochemically controlled acromegalic patients showed signifi cantly higher CCT and IOP levels and lower RNFL thickness compared to healthy controls and the duration of disease was correlated with CCT and IOP levels.en_US
dc.identifier.citationSen Emine, Tutuncu Yasemin, Elgin Ufuk, Balikoglu Yilmaz Melike, Berker Dilek, Nur Aksakal F, Ozturk Faruk, Guler Serdar. Comparing acromegalic patients to healthy controls with respect to intraocular pressure, central corneal thickness, and optic disc topography findings. Indian Journal of Ophthalmology. 2014 Aug ; 62 (8): 841-845.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/155723
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185160/en_US
dc.subjectcentral corneal thicknessen_US
dc.subjectintraocular pressureen_US
dc.subjectoptic disc topographyen_US
dc.subjectretinal nerve fi ber layer thicknessen_US
dc.titleComparing acromegalic patients to healthy controls with respect to intraocular pressure, central corneal thickness, and optic disc topography findings.en_US
dc.typeArticleen_US
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