In vitro chemosensitivity profile of oral squamous cell cancer and its correlation with clinical response to chemotherapy.

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dc.contributor.authorPathak, K Aen_US
dc.contributor.authorJuvekar, A Sen_US
dc.contributor.authorRadhakrishnan, D Ken_US
dc.contributor.authorDeshpande, M Sen_US
dc.contributor.authorPai, V Ren_US
dc.contributor.authorChaturvedi, Pen_US
dc.contributor.authorPai, P Sen_US
dc.contributor.authorChaukar, D Aen_US
dc.contributor.authorD'Cruz, A Ken_US
dc.contributor.authorParikh, P Men_US
dc.date.accessioned2009-05-28T07:04:43Z
dc.date.available2009-05-28T07:04:43Z
dc.date.issued2007-10-07en_US
dc.description.abstractCONTEXT: Oral cancers represent a disparate group of tumors with diverse clinical behavior and chemosensitivity profile. Currently, it is difficult to predict whether a tumor will respond to chemotherapy and which drug(s) will achieve the maximum clinical response. AIMS: To study in vitro chemosensitivity profile of oral cancers and to correlate the in vitro chemosensitivity of oral cancer to clinical response to chemotherapy. SETTINGS AND DESIGN: Prospective study in a tertiary cancer care center. METHODS AND MATERIAL: We prospectively studied the chemosensitivity profile of 57 untreated, advanced, unresectable oral cancers to cisplatin, methotrexate, 5-fluorouracil and their combinations by using histoculture drug response assay (HDRA) and correlated them to the clinical response to chemotherapy. STATISTICAL ANALYSIS USED: Chi Square test. RESULTS: Biopsy samples were successfully histocultured in 52/57 (91%) cases. Of these 52 evaluable patients, 47 had primary gingivo-buccal cancers and five had tongue / floor of mouth cancers. Based on the assay, 27 (52%) tumors were sensitive to cisplatin, 27 (52%) to methotrexate, 24 (46%) to 5-fluorouracil, 38 (73%) to combination of cisplatin and methotrexate and 36 (69%) to combination of cisplatin and 5-fluorouracil. Of these, 31 patients with good performance status received two cycles of chemotherapy using one or more of these test drugs. There was a significant correlation (p=0.03) between the in vitro chemosensitivity and the clinical response. Negative predictive value of the test was 80%, positive predictive value-69%, sensitivity-79% and specificity -71%. The overall accuracy of the assay was 74%. CONCLUSIONS: We found HDRA to be a fairly good predictor of chemo-response of oral cancer.en_US
dc.description.affiliationHead and Neck Service, Department of Surgery, Tata Memorial Hospital, Parel, Mumbai, India. kapathak@rediffmail.comen_US
dc.identifier.citationPathak KA, Juvekar AS, Radhakrishnan DK, Deshpande MS, Pai VR, Chaturvedi P, Pai PS, Chaukar DA, D'Cruz AK, Parikh PM. In vitro chemosensitivity profile of oral squamous cell cancer and its correlation with clinical response to chemotherapy. Indian Journal of Cancer. 2007 Oct-Dec; 44(4): 142-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/50825
dc.language.isoengen_US
dc.source.urihttps://www.indianjcancer.comen_US
dc.subject.meshAntimetabolites, Antineoplastic --pharmacologyen_US
dc.subject.meshAntineoplastic Agents --pharmacologyen_US
dc.subject.meshBiological Assayen_US
dc.subject.meshCarcinoma, Squamous Cell --drug therapyen_US
dc.subject.meshCisplatin --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorouracil --pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMethotrexate --pharmacologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMouth Neoplasms --drug therapyen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleIn vitro chemosensitivity profile of oral squamous cell cancer and its correlation with clinical response to chemotherapy.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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