Assessment of Efficacy and Safety of Fixed Dose Combination of 3% Biophytex LS 8740 and 5% Proteasyl TP LS 8657 Cream in the Treatment of Under Eye Dark Circles (Infra-orbital Hyperchromia).
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Date
2012-11
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Abstract
Background: Under Eye Dark Circles is attributed to
multiple factors. The treatment should address the various
pathologies involved to provide the best possible effects.
Aims: To assess the efficacy and safety of Wunder eye
cream (a combination of 3% Biophytex LS 8740 and 5%
Proteasyl TP LS 8657) in patients with under eye dark
circles. Study Design: Open label, prospective, single arm
and multicentric post marketing surveillance clinical study.
Materials and Methods: 142 patients (125 males and 17
females) were evaluated in the study. Wunder Eye cream
was applied twice daily on the affected under eye dark
circle area for eight weeks. Parameters evaluated were area
of under eye pigmentation, improvement in luminance of
under eye skin, reduction in under eye puffiness and
reduction in under eye wrinkles using a digital camera
photographs after four and eight weeks of treatment. Safety
evaluation was also done on the same time. The values
were compared using Chi-Square test. Results: Early
response was seen in 40% of patients with four weeks of
treatment where 50% improvement in all the parameters
was seen. With eight weeks of therapy about 92.3% of
patients showed 50 to 100% improvement in the area of
under eye pigmentation; 50% to 75% improvement was
seen in 87.3% of patients for under eye pigmentation, in
80.1% patients for luminance of under eye skin, in 68%
patients for under eye puffiness and in 67.4% of patients
for under eye wrinkles. Conclusion: Wunder eye cream is
a combination of botanical and yeast extracts was found to
be effective against under eye dark circles.
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Keywords
under eye dark circles, biophytex LS 8740, proteasyl TP LS 8657
Citation
Kharkar R D, Ahluwalia A, Karankumar J, Phadke N. SAssessment of Efficacy and Safety of Fixed Dose Combination of 3% Biophytex LS 8740 and 5% Proteasyl TP LS 8657 Cream in the Treatment of Under Eye Dark Circles (Infra-orbital Hyperchromia). Indian Medical Gazette. 2012 Nov ; 145 (11): 440-445.