Possible role of histamine receptors in the central regulation of immune responses.

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dc.contributor.authorMoharana, A Ken_US
dc.contributor.authorBhattacharya, S Ken_US
dc.contributor.authorMediratta, P Ken_US
dc.contributor.authorSharma, K Ken_US
dc.date.accessioned2000-04-10en_US
dc.date.accessioned2009-06-01T06:39:26Z
dc.date.available2000-04-10en_US
dc.date.available2009-06-01T06:39:26Z
dc.date.issued2000-04-10en_US
dc.description.abstractThe present study was designed to delineate the role of H1- and H2-histamine receptors in the neuro-immune regulation in rats. The effects of H1- and H2-receptor antagonists on humoral and cell-mediated immune (HI and CMI) responses were investigated after intraperitoneal (i.p.) and intra-cerebroventricular (i.c.v.) administration. HI response was assayed by anti-sheep red blood cell (SRBC) antibody titre in presence and absence of 2-mercaptoethanol (2-ME). The CMI responses were evaluated by delayed type hypersensitivity (DTH) reaction (in vivo), i.e., measurement of footpad thickness, and lymphokine activity such as leucocyte migration inhibition (LMI) test (in vitro). On i.p. administration, both H1- (pheniramine and astemizole) and H2-receptor antagonists (ranitidine and cimetidine) were observed to produce significant enhancement of anti-SRBC antibody response. However, only H2- and not H1-receptor blockers were observed to stimulate CMI response significantly. When administered by icv route, only H2-receptor antagonists caused a statistically significant increase in both HI and CMI responses, while the H1-receptor blockers failed to modify the same. Thus, H2-receptors appear to play a major role in the histaminergic mechanisms involved in immunomodulation both at the level of immunocompetent cells active in the peripheral tissues as well as through the central nervous system structures involved in the central regulation of neuro-immune interaction.en_US
dc.description.affiliationDepartment of Pharmacology, University College of Medical Sciences & GTB Hospital, Shahdara, Delhi.en_US
dc.identifier.citationMoharana AK, Bhattacharya SK, Mediratta PK, Sharma KK. Possible role of histamine receptors in the central regulation of immune responses. Indian Journal of Physiology and Pharmacology. 2000 Apr; 44(2): 153-60en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107555
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibody Formation --drug effectsen_US
dc.subject.meshCell Migration Inhibitionen_US
dc.subject.meshCentral Nervous System --physiologyen_US
dc.subject.meshErythrocytes --immunologyen_US
dc.subject.meshHistamine --pharmacologyen_US
dc.subject.meshHistamine H1 Antagonists --administration & dosageen_US
dc.subject.meshHistamine H2 Antagonists --administration & dosageen_US
dc.subject.meshImmunity, Cellular --drug effectsen_US
dc.subject.meshInjections, Intraventricularen_US
dc.subject.meshMaleen_US
dc.subject.meshNeuroimmunomodulation --physiologyen_US
dc.subject.meshPeripheral Nervous System --drug effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshReceptors, Histamine H1 --drug effectsen_US
dc.subject.meshReceptors, Histamine H2 --drug effectsen_US
dc.titlePossible role of histamine receptors in the central regulation of immune responses.en_US
dc.typeJournal Articleen_US
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