Incidence of tuberculosis in nondialysis-requiring CKD patients

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dc.contributor.authorNarain, Upmaen_US
dc.contributor.authorGupta, Arvinden_US
dc.date.accessioned2020-04-09T07:39:13Z
dc.date.available2020-04-09T07:39:13Z
dc.date.issued2018-01
dc.description.abstractBackground: Tuberculosis is a common infection of chronic kidney disease patients in developing countries.Methods: A retrospective study of 2960 non-dialysis requiring chronic kidney disease patients was made to determine the incidence and understand the demographic features of patients that lead to the development of tuberculosis on the basis of cell count, routine, ADA estimation, ZN stain, culture and PCR.Results: Between Jan 2000 and March 2017, the incidence of tuberculosis in no dialysis-requiring chronic kidney disease group was 10.3% in which pulmonary tuberculosis was 3.9% while extrapulmonary tuberculosis was 6.4%. Among extrapulmonary tuberculosis, 52% positivity was seen in pleural effusion, 16.40% in ascetic fluid, 10.10% in lymphnodes, 7.4% in urinary tract, and 3.7% in CSF, 2.6% in pericardial fluid, 1.6% in adrenal tissue and 1.1% in spine. ZN stain was positive in 48.6%, culture isolated mycobacterium 98.3%, PCR 93.4%, the mean ADA levels was 22.90+11.24 IU/ml and 60.49+07.24 IU/ml in CSF and body fluids respectively. Outcome analysis revealed 15.4% mortality rate in diagnosed tuberculosis cases while maximum loss of life was seen in diabetic patients.Conclusions:In the present study we observed 10.3% incidence of tuberculosis among nondialysis-requiring chronic kidney disease patients. Extrapulmonary form of tuberculosis predominates over pulmonary form. Unusual presentation and lococalization of symptoms should not be overlooked. Prompt and early diagnosis of tuberculosis is especially required in endemic areas.en_US
dc.identifier.affiliationsDepartment of Microbiology, Tejas Microdiagnostics, Allahabad, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Nephrology, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, Indiaen_US
dc.identifier.citationNarain Upma, Gupta Arvind. Incidence of tuberculosis in nondialysis-requiring CKD patients. International Journal of Advances in Medicine. 2018 Jan; 5(1): 141-144en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/193878
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber1en_US
dc.relation.volume5en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3933.ijam20180073en_US
dc.subjectChronic kidney diseaseen_US
dc.subjectExtrapulmonaryen_US
dc.subjectNondialysis-requiringen_US
dc.subjectPulmonaryen_US
dc.subjectTuberculosisen_US
dc.titleIncidence of tuberculosis in nondialysis-requiring CKD patientsen_US
dc.typeJournal Articleen_US
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