Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far

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dc.contributor.authorAgrawal, Men_US
dc.contributor.authorVardhan, Gen_US
dc.contributor.authorKumar, Ven_US
dc.contributor.authorDhamija, P.en_US
dc.date.accessioned2023-06-27T06:37:58Z
dc.date.available2023-06-27T06:37:58Z
dc.date.issued2022-07
dc.description.abstractIn 2019, a new variant of coronavirus emerged that put the whole world on a standstill due to its unprecedented spread and morbidity. Since then, scientists have been working on several theories to explain the origin and pathogenesis of the virus. Over this period of time, it has been observed clinically that individual variation exists in the way this virus infects people, its symptomatology and sequelae. The pathophysiology is still unclear. This review was taken up to consolidate all the available information until date about current theories of etiopathogenesis with an understanding of potential therapeutic targets on the mechanisms. This review also highlights the gray areas that need to be addressed in the future. Research papers published up to December 7, 2020 were included based on a search on PubMed, Google Scholar, etc., to get the latest relevant literature on this topic. Coronavirus expresses differently in different individuals, affecting different organ systems, and having variable severity. However, the underlying pathogenic mechanisms are not completely understood. Due to the lack of definite curative therapy, it is essential to explore the basic pathophysiology so as to develop more effective and target-based therapies in the future.en_US
dc.identifier.affiliationsDepartment of Physiology, Government Medical College, Haldwani, Uttarakhand, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, Indiaen_US
dc.identifier.citationAgrawal M, Vardhan G, Kumar V, Dhamija P. . Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far. National Journal of Physiology, Pharmacy and Pharmacology. 2022 Jul; 12(7): 907-915en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/217612
dc.languageenen_US
dc.publisherMrs Dipika Charan of MedScience (India) Publicationsen_US
dc.relation.issuenumber7en_US
dc.relation.volume12en_US
dc.source.urihttps://dx.doi.org/10.5455/njppp.2022.12.05135202223052022en_US
dc.subjectCOVID-19en_US
dc.subjectCurrent Theoriesen_US
dc.subjectPathophysiologyen_US
dc.subjectPotential Targetsen_US
dc.subjectEtiopathogenesisen_US
dc.subjectUnprecedented Spreaden_US
dc.titleCurrent theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so faren_US
dc.typeJournal Articleen_US
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