Oral contraceptives and intrauterine devices as risk factors for breast and cervical cancers: a systematic review

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dc.contributor.authorMurithi, Mary K.en_US
dc.contributor.authorOgeto, Teresa K.en_US
dc.contributor.authorWalekhwa, Michael N.en_US
dc.contributor.authorNjunge, Richard K.en_US
dc.contributor.authorLagat, Micah K.en_US
dc.contributor.authorMalago, Zablon L.en_US
dc.date.accessioned2020-11-18T10:01:40Z
dc.date.available2020-11-18T10:01:40Z
dc.date.issued2020-06
dc.description.abstractBreast and cervical cancers have commandingly become major public health threats across the world. While studies have reported on the nexus between the use of oral contraceptives (OCs) and intrauterine devices (IUDs) as risk factors for breast and cervical cancers, there exists a paucity of explicit data on the nature of the association. Authors report the effect of oral contraceptives and the use of IUDs on the development of breast and cervical cancers. Several databases (Cochrane Library, Google Scholar and PubMed) were searched using well-specified criteria and a total of 15 papers selected. Meta-analyses, systematic reviews and studies that used cross-sectional designs were excluded from the review. Three and twelve cohort and case-control studies were reviewed respectively. Four of these studies reported an increased association between oral contraceptives and the risk of cervical cancer while nine showed positive correlation between oral contraceptives and risk of breast cancer. One study showed association between levonogestrel IUDs and risk of breast cancer while the other study did not show association between both levonogestrel and copper IUDs with risk of breast cancer. Use of copper IUDs was associated with diminishing risk of cervical cancer. Overall, use of oral contraceptives upsurges risk of breast and cervical cancers especially when used for longer periods of time. Further studies should therefore be done to understand the mechanisms of action of oral contraceptives and IUDs on the development of both cancers.en_US
dc.identifier.affiliationsDepartment of Pre-Clinical, School of Pharmacy, Kabarak University, Nakuru, Kenyaen_US
dc.identifier.affiliationsDepartment of Biomedical Sciences, School of Medicine and Health Sciences, Kabarak University, Nakuru, Kenyaen_US
dc.identifier.affiliationsDepartment of Pharmacology and Pharmacognosy, School of Pharmacy, Kabarak University, Nakuru, Kenyaen_US
dc.identifier.citationMurithi Mary K., Ogeto Teresa K., Walekhwa Michael N., Njunge Richard K., Lagat Micah K., Malago Zablon L.. Oral contraceptives and intrauterine devices as risk factors for breast and cervical cancers: a systematic review. International Journal of Research in Medical Sciences. 2020 May; 8(5): 2350-2359en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/212295
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber5en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20202294en_US
dc.subjectBreast canceren_US
dc.subjectCervical canceren_US
dc.subjectIntrauterine devicesen_US
dc.subjectLevonogestrelen_US
dc.subjectOral contraceptivesen_US
dc.subjectRisk factoren_US
dc.titleOral contraceptives and intrauterine devices as risk factors for breast and cervical cancers: a systematic reviewen_US
dc.typeJournal Articleen_US
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