Comparison of oral nifedipine and oral labetalol as a single drug therapy for control of blood pressure in preeclampsia

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dc.contributor.authorPatel, Alpesh R.en_US
dc.contributor.authorArora, Sneha R.en_US
dc.contributor.authorBhatt, Jalpa K.en_US
dc.date.accessioned2020-10-16T08:05:00Z
dc.date.available2020-10-16T08:05:00Z
dc.date.issued2020-06
dc.description.abstractBackground: Worldwide hypertension during pregnancy is a common cause of maternal and fetal morbidity and mortality. Effective control of blood pressure is one of the important steps in management of preeclampsia. Few drugs like nifedipine, labetalol, methyldopa, and hydralazine have acceptable high safety profile during pregnancy.Methods: In this study 120 antenatal women with non-severe preeclampsia were compared by giving either nifedipine or labetalol as a single drug therapy for control of blood pressure. Various parameters like control of blood pressure, side effects of drugs, gestational age at the time of delivery, mode of delivery, any complication and perinatal outcome were assessed.Results: In this study authors found that in both group, adequate control of blood pressure was achieved. This study shows slightly higher rate of pre term delivery and LSCS with labetalol and minimal side effects with nifedipine but difference in each group is insignificant.Conclusions: Labetalol and nifedipine both the drugs are equally effective in reducing blood pressure and any of it can safely be used as a first choice of drug for management of hypertension in preeclampsia and it can be decided as per clinician’s experience and familiarity with drug.en_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Dr. M. K. Shah Medical College and Research Centre, Ahmedabad, Gujarat, Indiaen_US
dc.identifier.citationPatel Alpesh R., Arora Sneha R., Bhatt Jalpa K.. Comparison of oral nifedipine and oral labetalol as a single drug therapy for control of blood pressure in preeclampsia. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2020 Jun; 9(6): 2328-2332en_US
dc.identifier.issn2320-1770
dc.identifier.issn2320-1789
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/207745
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber6en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-1770.ijrcog20202306en_US
dc.subjectAntihypertensiveen_US
dc.subjectLabetalolen_US
dc.subjectNifedipineen_US
dc.subjectNon severe preeclampsiaen_US
dc.titleComparison of oral nifedipine and oral labetalol as a single drug therapy for control of blood pressure in preeclampsiaen_US
dc.typeJournal Articleen_US
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