Macular edema in Asian Indian premature infants with retinopathy of prematurity: Impact on visual acuity and refractive status after 1‑year.

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dc.contributor.authorVinekar, Anand
dc.contributor.authorMangalesh, Shwetha
dc.contributor.authorJayadev, Chaitra
dc.contributor.authorBauer, Noel
dc.contributor.authorMunusamy, Sivakumar
dc.contributor.authorKemmanu, Vasudha
dc.contributor.authorKurian, Mathew
dc.contributor.authorMahendradas, Padmamalini
dc.contributor.authorAvadhani, Kavitha
dc.contributor.authorShetty, Bhujang
dc.date.accessioned2016-01-12T10:43:37Z
dc.date.available2016-01-12T10:43:37Z
dc.date.issued2015-05
dc.description.abstractPurpose: To report the impact of transient, self‑resolving, untreated “macular edema” detected on spectral domain optical coherence tomography in Asian Indian premature infants with retinopathy of prematurity (ROP) on visual acuity (VA) and refraction at 1‑year of corrected age. Materials and Methods: Visual acuity and refraction of 11 infants with bilateral macular edema (Group A) was compared with gestational age‑matched 16 infants with ROP without edema (Group B) and 17 preterms infants without ROP and without edema (Group C) at 3, 6, 9 and 12 months of corrected age using Teller Acuity Cards and cycloplegic retinoscopy. Sub‑group analysis of the previously described pattern A and B macular edema was performed. Results: Visual acuity was lower in infants with macular edema compared with the other two control groups throughout the study period, but statistically significant only at 3 months. Visual improvement in these infants was highest between the 3rd and 6th month and plateaued by the end of the 1st year with acuity comparable to the other two groups. The edema cohort was more hyperopic compared to the other two groups between 3 and 12 months of age. Pattern A edema had worse VA compared to pattern B, although not statistically significant. Conclusion: Macular edema, although transient, caused reduced VA as early as 3 months of corrected age in Asian Indian premature infants weighing <2000 g at birth. The higher hyperopia in these infants is possibly due to visual disturbances caused at a critical time of fovealization. We hypothesize a recovery and feedback mechanism based on the principles of active emmetropization to explain our findings.en_US
dc.identifier.citationVinekar Anand, Mangalesh Shwetha, Jayadev Chaitra, Bauer Noel, Munusamy Sivakumar, Kemmanu Vasudha, Kurian Mathew, Mahendradas Padmamalini, Avadhani Kavitha, Shetty Bhujang. Macular edema in Asian Indian premature infants with retinopathy of prematurity: Impact on visual acuity and refractive status after 1‑year. Indian Journal of Ophthalmology. 2015 May; 63(5): 432-437.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/170363
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501141/en_US
dc.subjectEmmetropizationen_US
dc.subjecthand‑helden_US
dc.subjectmacular edemaen_US
dc.subjectretinopathy of prematurityen_US
dc.subjectspectral‑domain optical coherence tomographyen_US
dc.subjectvisual acuityen_US
dc.titleMacular edema in Asian Indian premature infants with retinopathy of prematurity: Impact on visual acuity and refractive status after 1‑year.en_US
dc.typeArticleen_US
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