Overview of a collaborative global effort to address the burden of familial hypercholesterolaemia

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dc.contributor.authorLyons, Alexander R.M.en_US
dc.contributor.authorStevens, Christophe A.T.en_US
dc.contributor.authorDharmayat, Kanika I.en_US
dc.contributor.authorVallejo-Vaz, Antonio J.en_US
dc.contributor.authorRay, Kausik K.en_US
dc.date.accessioned2025-05-09T07:17:55Z
dc.date.available2025-05-09T07:17:55Z
dc.date.issued2024-03
dc.description.abstractThis is an overview of the EAS Familial Hypercholesterolaemia (FH) Studies Collaboration (FHSC) global con- sortium and registry (established 2015), which broadly addresses the global burden of FH. Eighty-seven National Lead Investigators from 74 countries form this expanding global consortium, and this global registry currently includes pooled data on 70,000 participants from participating countries to facilitate FH surveillance. Published first results from this global registry concluded that FH is diagnosed late, and management of LDL-cholesterol falls below guideline recommendations, and therefore earlier detection of FH and wider use of combination therapy is required. Further FHSC studies will follow on updated data including new countries, participants and variables, and non-DNA genetic information, and on the remaining cohorts in the registry. FHSC cross-sectional collaborative global studies are expected to promote FH detection earlier in life to subsequently initiate early lipid lowering therapy to reduce lifelong exposure to cumulative LDL-cholesterol thus reducing cardiovascular disease risk.en_US
dc.identifier.affiliationsImperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, School of Public Health, Imperial College London, London, United Kingdomen_US
dc.identifier.affiliationsImperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, School of Public Health, Imperial College London, London, United Kingdomen_US
dc.identifier.affiliationsImperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, School of Public Health, Imperial College London, London, United Kingdomen_US
dc.identifier.affiliationsImperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, School of Public Health, Imperial College London, London, United Kingdom; Department of Medicine, Faculty of Medicine, University of Seville, Seville, Spain; Clinical Epidemiology and Vascular Risk, Instituto de Biomedicina de Sevilla, IBiS, Hospital Universitario Virgen Del Roco, Universidad de Sevilla, CSIC, Seville, Spainen_US
dc.identifier.affiliationsImperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, School of Public Health, Imperial College London, London, United Kingdomen_US
dc.identifier.citationLyons Alexander R.M., Stevens Christophe A.T., Dharmayat Kanika I., Vallejo-Vaz Antonio J., Ray Kausik K. . Overview of a collaborative global effort to address the burden of familial hypercholesterolaemia. Indian Heart Journal. 2024 Mar; 76(1): 113-116en_US
dc.identifier.issn0019-4832
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/242781
dc.languageenen_US
dc.publisherElsevieren_US
dc.relation.issuenumber1en_US
dc.relation.volume76en_US
dc.source.urihttps://doi.org/10.1016/j.ihj.2023.11.005en_US
dc.subjectFamilial hypercholesterolaemiaen_US
dc.subjectHypercholesterolaemiaen_US
dc.subjectDyslipidaemiasen_US
dc.subjectAtherosclerosisen_US
dc.subjectRegistryen_US
dc.subjectLDL-Cholesterolen_US
dc.subjectFHSCen_US
dc.titleOverview of a collaborative global effort to address the burden of familial hypercholesterolaemiaen_US
dc.typeJournal Articleen_US
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