Comparative efficacy of continuous and pulse dose terbinafifine regimes in toenail dermatophytosis: A randomized double-blind trial.

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dc.contributor.authorYadav, Pravesh
dc.contributor.authorSingal, Archana
dc.contributor.authorPandhi, Deepika
dc.contributor.authorDas, Shukla
dc.date.accessioned2015-07-18T11:16:56Z
dc.date.available2015-07-18T11:16:56Z
dc.date.issued2015-07
dc.description.abstractIntroduction: Dermatophytes are the most frequently implicated agents in toenail onychomycosis and oral terbinafi ne has shown the best cure rates in this condition. The pharmacokinetics of terbinafi ne favors its effi cacy in pulse dosing. Objectives: To compare the effi cacy of terbinafi ne in continuous and pulse dosing schedules in the treatment of toenail dermatophytosis. Methods: Seventy-six patients of potassium hydroxide (KOH) and culture positive dermatophyte toenail onychomycosis were randomly allocated to two treatment groups receiving either continuous terbinafi ne 250 mg daily for 12 weeks or 3 pulses of terbinafi ne (each of 500mg daily for a week) repeated every 4 weeks. Patients were followed up at 4, 8 and12 weeks during treatment and post-treatment at 24 weeks. At each visit, a KOH mount and culture were performed. In each patient, improvement in a target nail was assessed using a clinical score; total scores for all nails and global assessments by physician and patient were also recorded. Mycological, clinical and complete cure rates, clinical effectivity and treatment failure rates were then compared. Results: The declines in target nail and total scores from baseline were signifi cant at each follow-up visit in both the treatment groups. However, the inter-group difference was statistically insignifi cant. The same was true for global assessment indices, clinical effectivity as well as clinical, mycological, and complete cure rates. Limitations: The short follow-up in our study may have led to lower cure rates being recorded. Conclusion: Terbinafi ne in pulse dosing is as effective as continuous dosing in the treatment of dermatophyte toenail onychomycosis.en_US
dc.identifier.citationYadav Pravesh, Singal Archana, Pandhi Deepika, Das Shukla. Comparative effifi cacy of continuous and pulse dose terbinafifi ne regimes in toenail dermatophytosis: A randomized double-blind trial. Indian Journal of Dermatology, Venereology and Leprology. 2015 Jul-Aug; 81(4): 363-369.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/160055
dc.language.isoenen_US
dc.source.urihttps://www.ijdvl.com/article.asp?issn=0378-6323;year=2015;volume=81;issue=4;spage=363;epage=369;aulast=Yadaven_US
dc.subjectDermatophyteen_US
dc.subjectonychomycosisen_US
dc.subjectpulseen_US
dc.subjectterbinafineen_US
dc.subjecttoe-nailsen_US
dc.subjecttinea unguiumen_US
dc.subject.meshArthrodermataceae --drug effects
dc.subject.meshDouble Blind Method
dc.subject.meshHumans
dc.subject.meshNaphthalenes --administration & dosage
dc.subject.meshNails --microbology
dc.subject.meshOnychomycosis --drug therapy
dc.subject.meshOnychomycosis --epidemiolgy
dc.subject.meshPulse Therapy, Drug --methods
dc.subject.meshTinea --drug therapy
dc.subject.meshTinea --epidemiology
dc.subject.meshToes --microbiology
dc.titleComparative efficacy of continuous and pulse dose terbinafifine regimes in toenail dermatophytosis: A randomized double-blind trial.en_US
dc.typeArticleen_US
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