The association of Gγ XmnI polymorphism with hemoglobin F levels in homozygous hemoglobin E

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dc.contributor.authorNaruwat Pakdeeen_US
dc.contributor.authorKomgrid Sukmaitreeen_US
dc.contributor.authorGoonnapa Fucharoenen_US
dc.contributor.authorSupan Fucharoenen_US
dc.contributor.authorKanokwan Sanchaisuriyaen_US
dc.contributor.authorNattaya Sae-ungen_US
dc.date.accessioned2011-02-20T04:32:55Z
dc.date.available2011-02-20T04:32:55Z
dc.date.created2010-01-20en_US
dc.date.issued2010-01-20en_US
dc.description.abstractThe Gγ -Xmn I polymorphism (-158 C → T) in 131 subjects with homozygous Hb E were investigated. The Xmn I (+/+), (+/-) and (-/-) patterns were identified in 77 (58.8 %), 45 (34.3 %) and 9 (6.9 %) cases, respectively. This result indicates that majority of βE globin genes are linked to the Xmn I + allele. Among 61 cases of Hb E homozygote (Hb \> 9 g/dl) who had (bE/bE, aa/aa) genotype, 37 (59.7 %), 20 (32.3 %) and 5 (8.0 %) cases had the Xmn I (+ / +), (+ / -) and (- / -) patterns, respectively. The median levels of Hb E and other Rbc parameters in these groups were not difference. However, the median levels of Hb F as determined by Hb-HPLC analysis, the MCHF (ng) and the Hb F concentration (mg/dl) were significantly higher in the Xmn I (+ / +) group (3.6 %, 731.0 ng and 374.0 mg/dl) as compared to those with the Xmn I (+ / -) (2.4 %, 456.9 ng and 264.4 mg/dl) and the Xmn I (- / -) (2.5 %, 518.0 ng and 245.0 mg/dl) at p-value \< 0.01 using Kruskal Wallis One-way Analysis of Variance and Mann-Whitney U-Test. No difference was found between the Xmn I (+ / -) and the Xmn I (- / -) groups. Although the Gγ -Xmn I (+ / +) polymorphism is associated with high Hb F production in Hb E homozygote, it is apparent that other factors requiring further investigation might also be involved.en_US
dc.identifier.citationJournal of Medical Technology and Physical Therapy; Volume 19 Number 1, January - April 2007en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/130862
dc.language.isoen_USen_US
dc.publisherKhon Kaen Universityen_US
dc.rightsKhon Kaen Universityen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/JMTPT/issue/archiveen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/JMTPT/article/view/580en_US
dc.titleThe association of Gγ XmnI polymorphism with hemoglobin F levels in homozygous hemoglobin Een_US
dc.typeORIGINAL ARTICLEen_US
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