Outcomes of neonatal retinoblastoma in pre-chemotherapy and chemotherapy eras

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dc.contributor.authorCamp, DAen_US
dc.contributor.authorDalvin, LAen_US
dc.contributor.authorSchwendeman, Ren_US
dc.contributor.authorLim, LASen_US
dc.contributor.authorShields, CLen_US
dc.date.accessioned2020-04-10T02:05:31Z
dc.date.available2020-04-10T02:05:31Z
dc.date.issued2019-12
dc.description.abstractPurpose: To quantify outcomes for neonatal retinoblastoma patients treated during the pre-chemotherapy (1980�1994) and chemotherapy (1995�2018) eras. Methods: Retrospective review of retinoblastoma patients diagnosed within the first 28 days of life between 1/1/1980 and 11/30/2018. Student's t-test, Chi-square, and Fisher's exact test were performed to compare treatments and outcomes by era. Results: There were 68 patients with neonatal retinoblastoma (12% unilateral and 88% bilateral). According to era (pre-chemotherapy vs. chemotherapy), the number of treated patients was 26 (38%) vs. 42 (62%). Primary treatment was external beam radiotherapy (50% vs. 1%,P < 0.001), plaque radiotherapy (17% vs. 0%,P < 0.001), focal treatment (transpupillary thermotherapy or cryotherapy) only (21% vs. 14%,P= 0.33), intravenous chemotherapy (0% vs. 81%,P < 0.001), enucleation (10% vs. 4%,P= 0.26), or exenteration (2% vs. 0%,P= 0.37). Outcomes included tumor control (79% vs. 94%,P= 0.02), globe salvage (75% vs. 91%,P= 0.02), final gross visual acuity for salvaged eyes 20/200 or better (66% vs. 89%,P < 0.01), and death (19% vs. 0%,P < 0.01). Conclusion: Chemotherapy advancements for neonatal retinoblastoma have improved tumor control, globe salvage, visual acuity, and patient survival.en_US
dc.identifier.affiliationsOcular Oncology Service, Wills Eye Hospital, Philadelphia, PA, USAen_US
dc.identifier.affiliationsOcular Oncology Service, Wills Eye Hospital, Philadelphia, PA; Department of Ophthalmology, Mayo Clinic, Rochester, MN, USAen_US
dc.identifier.citationCamp DA, Dalvin LA, Schwendeman R, Lim LAS, Shields CL. Outcomes of neonatal retinoblastoma in pre-chemotherapy and chemotherapy eras. Indian Journal of Ophthalmology. 2019 Dec; 67(12): 1997-2004en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/197645
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber12en_US
dc.relation.volume67en_US
dc.source.urihttps://dx.doi.org/10.4103/ijo.IJO_634_19en_US
dc.subjectCanceren_US
dc.subjectchemotherapyen_US
dc.subjecteyeen_US
dc.subjectintra-arterialen_US
dc.subjectintravenousen_US
dc.subjectintravitrealen_US
dc.subjectneonatalen_US
dc.subjectretinoblastomaen_US
dc.titleOutcomes of neonatal retinoblastoma in pre-chemotherapy and chemotherapy erasen_US
dc.typeJournal Articleen_US
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