Clinical profile and outcome of neonatal thrombocytopenia in a tertiary care hospital

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dc.contributor.authorMeena, Sumarth Lalen_US
dc.contributor.authorSingh, Kanwaren_US
dc.contributor.authorJain, Sanjiven_US
dc.contributor.authorJain, Anilen_US
dc.contributor.authorKarnawat, B. S.en_US
dc.date.accessioned2020-09-24T07:43:56Z
dc.date.available2020-09-24T07:43:56Z
dc.date.issued2019-05
dc.description.abstractBackground: Thrombocytopenia (platelet count <1,50,000/'L) is one of the most common haematological problems in neonatal intensive care units. In contrast, only 2% of the normal neonates are thrombocytopenic at birth with severe thrombocytopenia (platelet count <50,000/'L) occurring in less than 3/1000 term infants. Multiple disease processes can cause thrombocytopenia in neonates. The important causes of thrombocytopenia in neonates are sepsis, birth asphyxia, prematurity, intra-uterine growth retardation, hyperbilirubinemia, respiratory distress syndrome, meconium aspiration syndrome and low birth weight. Apart from platelet count, bleeding manifestations depend on underlying ailments. The aims and objective were to study the clinical profile, etiology and outcome of neonatal thrombocytopenia in a tertiary care hospital.Methods: Prospective study involving 100 neonates with or developed neonatal thrombocytopenia in NICU.Results: In present study, 100 new-borns with thrombocytopenia 46% were mild, 35% were moderate and 19% were severe thrombocytopenia. 51 (51%) had early onset neonatal thrombocytopenia and 49 (49%) babies had late onset neonatal thrombocytopenia. Anaemia was the dominant maternal predisposing risk factor. Sepsis was the most common cause of neonatal thrombocytopenia. Most common symptom was apnoea. Sepsis, RDS and NEC had significantly contributed to mortality. Most common cause of death was sepsis followed by RDS and NEC.Conclusions: Neonatal thrombocytopenia is a treatable and reversible condition. Hence, it is important to identify neonates at risk and initiate transfusion therapy to prevent severe bleeding and potentially significant morbidity. Anaemia and PROM were the commonest maternal risk factors. Therefore, author recommended that babies born to mothers with these risk factors should be closely monitored for thrombocytopenia.en_US
dc.identifier.affiliationsDepartment of Pediatrics, JLN Medical College and Hospital, Ajmer, Rajasthan, Indiaen_US
dc.identifier.citationMeena Sumarth Lal, Singh Kanwar, Jain Sanjiv, Jain Anil, Karnawat B. S.. Clinical profile and outcome of neonatal thrombocytopenia in a tertiary care hospital. International Journal of Contemporary Pediatrics. 2019 May; 6(3): 1344-1348en_US
dc.identifier.issn2349-3283
dc.identifier.issn2349-3291
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/204100
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber3en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3291.ijcp20192041en_US
dc.subjectBleedingen_US
dc.subjectMaternal anaemiaen_US
dc.subjectNeonatal thrombocytopeniaen_US
dc.subjectSepsisen_US
dc.titleClinical profile and outcome of neonatal thrombocytopenia in a tertiary care hospitalen_US
dc.typeJournal Articleen_US
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