Innovative Therapeutics in Neurodegenerative Disease: Current Advances and Future Directions

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dc.contributor.authorJoshi, P.en_US
dc.contributor.authorSingh, S.en_US
dc.contributor.authorDhariyal, R. S.en_US
dc.date.accessioned2025-06-19T06:00:14Z
dc.date.available2025-06-19T06:00:14Z
dc.date.issued2025-03
dc.description.abstractNeurodegenerative disorders, which are marked by gradual degeneration of the neurological system and intricate pathogenic pathways, provide a significant challenge to modern medicine. The focus of this thorough assessment is on innovative therapeutic techniques created between 2020 and 2023, with a particular emphasis on molecular therapies, biologics, and new technologies. The effectiveness of treatment has been greatly increased by recent developments in medication delivery methods, such as brain-targeting tactics and nano-carrier based ideas. The advent of diseasemodifying therapies, such as Lecanemab for Alzheimer's disease and new LRRK2 inhibitors for Parkinson's disease, signifies a change in focus from treating symptoms to addressing the underlying cause of the condition. Applications of artificial intelligence and machine learning have expedited the process of finding and developing new drugs, and sophisticated biomarker platforms have made it possible to precisely stratify patients. Not withstanding these successes, there are still major obstacles to overcome in the areas of cost control, healthcare implementation, and treatment optimization. The shift toward personalized medical methods and the integration of numerous therapeutic modalities for improved treatment outcomes are highlighted in this review, which critically examines recent advancements, cutting-edge technology, and future possibilities in neurodegenerative disease therapies.en_US
dc.identifier.affiliationsResearch Scholar, Department of Pharmacy, Siddhartha Institute of Pharmacology, Sahashtradhara Road, Near I.T Park, Do Bachi Road, Dehradun-248001, Uttarakhand, Indiaen_US
dc.identifier.affiliationsPrincipal, Siddhartha Institute of Pharmacy, Sahashtradhara Road, near I.T Park, Do Bachi Road, Dehradun, Uttarakhand, India; Contact-9456596303en_US
dc.identifier.affiliationsAssociate Professor, Siddhartha Institute of Pharmacy,Sahashtradhara Road,Near I.T Park Do Bachi Road, Dehradun-248001, Uttarakhand, India; Contact –7983995452en_US
dc.identifier.citationJoshi P., Singh S., Dhariyal R. S.. Innovative Therapeutics in Neurodegenerative Disease: Current Advances and Future Directions. Indian Journal of Preventive and Social Medicine. 2025 Mar; 56(1): 152-156en_US
dc.identifier.issn0301-1216
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249992
dc.languageenen_US
dc.publisherDepartment of Community Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi- 221005, India.en_US
dc.relation.issuenumber1en_US
dc.relation.volume56en_US
dc.source.urihttps://ijpsm.co.in/index.php/ijpsm/article/view/753en_US
dc.subjectNeuro-degenerative disordersen_US
dc.subjectDrug delivery systemsen_US
dc.subjectDisease-modifying therapiesen_US
dc.subjectArtificial intelligenceen_US
dc.subjectBiomarkersen_US
dc.subjectPersonalized medicineen_US
dc.subjectNanocarrier deliveryen_US
dc.subjectTreatment optimizatioen_US
dc.titleInnovative Therapeutics in Neurodegenerative Disease: Current Advances and Future Directionsen_US
dc.typeJournal Articleen_US
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