Comparison of standard short infusion versus prolonged infusion of Doxorubicin in relation to its cardiotoxicity in South Indian population

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dc.contributor.authorJacob, Roshan Koshyen_US
dc.contributor.authorKarpurmath, Shashidhar V.en_US
dc.contributor.authorNandennavar, Manjunathen_US
dc.contributor.authorAngadi, Veerendraen_US
dc.date.accessioned2020-11-18T10:00:11Z
dc.date.available2020-11-18T10:00:11Z
dc.date.issued2019-11
dc.description.abstractBackground: Anthracycline is one of the commonly used chemotherapeutic agents in the treatment of malignancies and their efficacy is undermined by potential life-threatening cardiotoxicity.  The aim of this study is to compare the cardiotoxicity in patients receiving standard short infusion (15-30 minutes) versus prolonged infusion (6 hours) of doxorubicin in the study group.Methods: In this study 80 patients who were planned for treatment with Doxorubicin >200 mg/m2 were included in this study and they were randomly allotted to either of the treatment group. Each patient was assessed clinically (History, Pulse rate, Blood pressure) along with ECG ,ECHO prior to initiation of chemotherapy, after completion of 200 mg/m2 of Doxorubicin, 3 months and 6 months after chemotherapy.Results: There were 40 patients in each group, and they received a total of 384 cycles of Doxorubicin containing regimens according to respective protocols. The median number of cycles was four (range four to six cycles). The mean cumulative dose of doxorubicin was 271.5 mg/m2 in the group which received standard short infusion and 264 mg/m2 in the group which received the drug by prolonged infusion. However, none of the patients developed any cardiac symptoms during or after the planned chemotherapy nor was there a drop in ejection fraction on serial ECHO.Conclusions: There was no benefit of prolonged infusion of doxorubicin as compared to the standard rapid infusion in terms of doxorubicin induced cardiotoxicity. At present, standard rapid infusion is the best option.en_US
dc.identifier.affiliationsDepartment of Medical Oncology, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, Indiaen_US
dc.identifier.citationJacob Roshan Koshy, Karpurmath Shashidhar V., Nandennavar Manjunath, Angadi Veerendra. Comparison of standard short infusion versus prolonged infusion of Doxorubicin in relation to its cardiotoxicity in South Indian population. International Journal of Research in Medical Sciences. 2019 Nov; 7(11): 4298-4305en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/211900
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber11en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20195005en_US
dc.subjectCardiotoxicity, Doxorubicin, ECHO, Infusionen_US
dc.titleComparison of standard short infusion versus prolonged infusion of Doxorubicin in relation to its cardiotoxicity in South Indian populationen_US
dc.typeJournal Articleen_US
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