Development and In-Vitro Evaluation of Vinpocetine Loaded Bi-Layer Tablet Using Different Polymers.
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Date
2012-12
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Abstract
The present study has investigated various ways to formulate a bi-layer tablet dosage form containing an
immediate release and a sustained release portion of a neuroprotective compound named vinpocetine. The
bi-layer matrix tablet was prepared by simple compression of the SR granules and IR granules of
vinpocetine. The sustained release effect of vinpocetine was achieved with polymers methocel K15M CR,
kollidon SR and carbomer 934P. Physical properties of powders, granules and the finished tablets were
evaluated. The drug release study of the tablets was studied for 2 hours in 0.1N HCl followed by 8 hours
in pH 6.8 phosphate buffer as media using United States Pharmacopoea (USP) XXII paddle type
dissolution apparatus. The effect of above mentioned polymers on vinpocetine release profile was
investigated. The MDT values of all the formulations were calculated and correlated with the rate
retardation capacity of drug release of the polymers used. The release rate of vinpocetine immediate
release layer was found to be influenced little by kollidon CL and direct compressible grade lactose. The
release rate, extent and mechanisms of sustained release layers were found to be governed by the nature
and the extent of the polymer used in the formulation. Kinetic modeling of dissolution profiles reveled
that vinpocetine release mechanism ranges from the anomalous / non – fickian transport to super case II
transport in the given situations. These studies indicated that the proper balance between a matrix forming
agent and a channeling agent can produce a drug dissolution profile similar to a theoretical dissolution
profile will overcome the disadvantages of conventional tablets of vinpocetine.
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Keywords
Vinpocetine, Bi-Layer Tablet, Sustained Release, Mean Dissolution Time, (MDT), Anomalous / non – Fickian transport, Super case-II.
Citation
Jha Mithilesh Kumar, Faruki Md Zakaria, Rahman Md Habibur, Rahman Md Mofizur, Talukder Md Mesbah Uddin. Development and In-Vitro Evaluation of Vinpocetine Loaded Bi-Layer Tablet Using Different Polymers. Journal of Applied Pharmaceutical Science. 2012 Dec; 2(12): 149-157.