Vitamin B12 deficiency & levels of metabolites in an apparently normal urban south Indian elderly population.

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dc.contributor.authorShobha, Vineeta
dc.contributor.authorTarey, Subhash D
dc.contributor.authorSingh, Ramya G
dc.contributor.authorShetty, Priya
dc.contributor.authorUnni, Uma S
dc.contributor.authorSrinivasan, Krishnamachari
dc.contributor.authorKurpad, Anura V
dc.date.accessioned2012-01-10T05:35:20Z
dc.date.available2012-01-10T05:35:20Z
dc.date.issued2011-10
dc.description.abstractBackground & objectives: There is no published literature on the extent of vitamin B12 deficiency in elderly Indians as determined by plasma vitamin B12 levels and methylmalonic acid (MMA) levels. Vitamin B12 deficiency is expected to be higher in elderly Indians due to vegetarianism, varied socio-economic strata and high prevalence of Helicobacter pylori infection. We therefore, studied the dietary habits of south Indian urban elderly population and measured vitamin B12, MMA red cell folate and homocysteine (Hcy) levels. Methods: Healthy elderly urban subjects (175, >60 yr) were recruited. Detailed history, physical examination and neurological assessment were carried out. Food Frequency Questionnaire (FFQ) for dietary analysis for daily intake of calories, vitamin B12, folate and detailed psychological assessment for cognitive functions was carried out. Blood samples were analyzed for routine haematology and biochemistry, vitamin B12, red cell folate, MMA and Hcy. Results: The mean age of the study population was 66.3 yr. Median values for daily dietary intake of vitamin B12 and folate were 2.4 and 349.2 μg/day respectively. Sixty two (35%) participants consumed multivitamin supplements. Plasma vitamin B12 level and the dietary intake of vitamin B12 was significantly correlated (P=0.157). Plasma vitamin B12 and Hcy were inversely correlated (P= -0.509). Red cell folate was inversely correlated with Hcy (P= -0.550). Significant negative correlation was observed between plasma vitamin B12 and MMA in the entire study population (P= -0.220). Subjects consuming vitamin supplements (n=62) had significantly higher plasma vitamin B12 levels, lower MMA levels and lower Hcy levels. There was no significant correlation between plasma vitamin B12, MMA, Hcy and red cell folate and any of the 10 cognitive tests including Hindi Mental Status Examination (HMSE). Interpretation & conclusions: Our study is indicative of higher vitamin B12 (2.4 μg/day) intakes in urban south Indian population. Thirty five per cent of the study population consumed multivitamin supplements and therefore, low plasma vitamin B12 levels were seen only in 16 per cent of the study subjects. However, MMA was elevated in 55 per cent and Hcy in 13 per cent of the subjects.en_US
dc.identifier.citationShobha Vineeta, Tarey Subhash D, Singh Ramya G, Shetty Priya, Unni Uma S, Srinivasan Krishnamachari, Kurpad Anura V. Vitamin B12 deficiency & levels of metabolites in an apparently normal urban south Indian elderly population. Indian Journal of Medical Research. 2011 Oct; 134(4): 432-439.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/136340
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237239/en_US
dc.subjectCognitive assessmenten_US
dc.subjectgeriatricen_US
dc.subjectmethylmalonic aciden_US
dc.subjectnutritionen_US
dc.subjectvitamin B12 deficiencyen_US
dc.subject.meshAged
dc.subject.meshDiet, Vegetarian
dc.subject.meshErythrocytes --metabolism
dc.subject.meshFemale
dc.subject.meshFolic Acid --blood
dc.subject.meshHelicobacter Infections --metabolism
dc.subject.meshHelicobacter pylori --isolation & purification
dc.subject.meshHomocysteine --blood
dc.subject.meshHumans
dc.subject.meshIndia --epidemiology
dc.subject.meshMale
dc.subject.meshMethylmalonic Acid --blood
dc.subject.meshMiddle Aged
dc.subject.meshVitamin B 12 --administration & dosage
dc.subject.meshVitamin B 12 --blood
dc.subject.meshVitamin B 12 --metabolism
dc.subject.meshVitamin B 12 Deficiency --blood
dc.subject.meshVitamin B 12 Deficiency --epidemiology
dc.subject.meshVitamin B 12 Deficiency --metabolism
dc.titleVitamin B12 deficiency & levels of metabolites in an apparently normal urban south Indian elderly population.en_US
dc.typeArticleen_US
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