Effects of low molecular weight galactomannans based standardized fenugreek seed extract in subjects with high fat mass: A randomized, double-blind, placebo-controlled clinical study

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dc.contributor.authorDeshpande, Pallavi Onkaren_US
dc.contributor.authorBele, Viveken_US
dc.contributor.authorJoshi, Kedaren_US
dc.contributor.authorThakurdesai, Prasad Arvinden_US
dc.date.accessioned2020-10-16T08:56:55Z
dc.date.available2020-10-16T08:56:55Z
dc.date.issued2020-01
dc.description.abstractThe present investigation evaluated the effects of low molecular weight galactomannans-based standardized fenugreekseeds extract (LMWGAL-TF) on human subjects with high-fat mass for 8-weeks using a prospective, randomized,double-blind, placebo-controlled design. Twenty-four subjects with percent body fat were randomized to ingest acapsule of LMWGAL-TF (500 mg, once a day) or the matching placebo at a 1:1 ratio for 8 weeks. The outcomemeasurements were recorded at baseline, week-4, and week-8 (end of the treatment). The efficacy outcome includedfat mass (absolute, non-fat mass and %) by skinfold thickness method (along with triceps, suprailiac, and abdominal)and bioelectrical impedance analysis method, body weight, body mass index, and abdominal girth. The standardsafety parameters were measured, such as adverse events, vital signs, hematology, and biochemistry. Eight weeksof LMWGAL-TF supplementation showed significant reduction in suprailiac skinfold thickness (v/s baseline) andabdominal skinfold thickness (v/s baseline and v/s placebo), and percent fat mass, (v/s baseline). The LMWGAL-TFsupplementation was found to be safe and well-tolerated. In conclusion, LMWGAL-TF supplementation showedsafety and efficacy in reducing skinfold thickness (abdominal and suprailiac) and percent body fat in subjects with ahigh fat massen_US
dc.identifier.affiliationsIndus Biotech Private Limited, 1, Rahul Residency, Off Salunke Vihar Road, Kondhwa, Pune 411048, Indiaen_US
dc.identifier.affiliationsHanul Medizin (India) LLP, E 1, Kaul Building, 8 Gurunanak Nagar, Off Shankershet Road, Pune 411 042, India.en_US
dc.identifier.affiliationsHanul Medizin (India) LLP, E 1, Kaul Building, 8 Gurunanak Nagar, Off Shankershet Road, Pune 411 042, Indiaen_US
dc.identifier.affiliationsIndus Biotech Private Limited, 1, Rahul Residency, Off Salunke Vihar Road, Kondhwa, Pune 411048, Indiaen_US
dc.identifier.citationDeshpande Pallavi Onkar, Bele Vivek, Joshi Kedar, Thakurdesai Prasad Arvind. Effects of low molecular weight galactomannans based standardized fenugreek seed extract in subjects with high fat mass: A randomized, double-blind, placebo-controlled clinical study. Journal of Applied Pharmaceutical Science. 2020 Jan; 2020 Jan: 062-069en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210745
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber1en_US
dc.relation.volume10en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2020.101008en_US
dc.subjectFenugreek seeden_US
dc.subjectlow molecular weight galactomannansen_US
dc.subjectfat massen_US
dc.subjectskinfold thicknessen_US
dc.subjectobesityen_US
dc.titleEffects of low molecular weight galactomannans based standardized fenugreek seed extract in subjects with high fat mass: A randomized, double-blind, placebo-controlled clinical studyen_US
dc.typeJournal Articleen_US
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