Renal histology in pauci-immune rapidly progressive glomerulonephritis: 8-year retrospective study.

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dc.contributor.authorMinz, Ranjana W
dc.contributor.authorChhabra, Seema
dc.contributor.authorJoshi, Kusum
dc.contributor.authorRani, Lekha
dc.contributor.authorSharma, Nidhi
dc.contributor.authorSakhuja, Vinay
dc.contributor.authorDuggal, Rajan
dc.contributor.authorPasricha, Neelam
dc.date.accessioned2012-10-16T04:02:37Z
dc.date.available2012-10-16T04:02:37Z
dc.date.issued2012-01
dc.description.abstractContext: The need to perform reporting of renal biopsies of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides in a more uniform manner required relook at our eight-year data. Aims: To document detailed renal histopathology of pauci-immune rapidly progressive glomerulonephritis (RPGN) and also to seek any significant differences in renal histology of C-ANCA-positive, P-ANCA-positive, and ANCA-negative patients. Materials and Methods: A detailed analysis of the histopathologic features of renal biopsies of 48 patients in whom a diagnosis of pauci-immune glomerulonephritis was concluded on renal biopsy and who presented clinically as rapidly progressive renal failure was done. Statistical Analysis Used: One-way ANOVA and Pearson Chi square tests. Results: Compared with ANCA +ve patients, the ANCA -ve patients were much younger (46.85 ± 16.12 years vs 34.28±15.94 years). No significant differences were found between renal lesions of C-ANCA, P-ANCA, and ANCA-negative patients, except for diffuse tubular atrophy which was more severe and more frequently present with P-ANCA positivity (P value=0.013). Conclusions: Pauci-immune RPGN (irrespective of ANCA status) is a relatively rare disorder in patients who are undergoing the renal biopsy at our institute, constituting 2% of all renal biopsies submitted. It is mandatory to have ANCA serology status during reporting of a kidney biopsy showing pauci-immune crescentic or necrotizing glomerulonephritis. Also, if a uniform reporting strategy is followed throughout the country, the studies from this vast country will be comparable.en_US
dc.identifier.citationMinz Ranjana W, Chhabra Seema, Joshi Kusum, Rani Lekha, Sharma Nidhi, Sakhuja Vinay, Duggal Rajan, Pasricha Neelam. Renal histology in pauci-immune rapidly progressive glomerulonephritis: 8-year retrospective study. Indian Journal of Pathology & Microbiology. 2012 Jan-Mar 55(1): 28-32.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142171
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=1;spage=28;epage=32;aulast=Minzen_US
dc.subjectHistologyen_US
dc.subjectpauci-immuneen_US
dc.subjectrapidly progressive glomerulonephritisen_US
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis --complications
dc.subject.meshAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis --pathology
dc.subject.meshAntibodies, Antineutrophil Cytoplasmic --blood
dc.subject.meshBiopsy
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshFemale
dc.subject.meshGlomerulonephritis --pathology
dc.subject.meshHistocytochemistry
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshInfant
dc.subject.meshKidney --pathology
dc.subject.meshMale
dc.subject.meshMicroscopy
dc.subject.meshMiddle Aged
dc.subject.meshRetrospective Studies
dc.titleRenal histology in pauci-immune rapidly progressive glomerulonephritis: 8-year retrospective study.en_US
dc.typeArticleen_US
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