Plasma ghrelin levels after laparoscopic sleeve gastrectomy in obese individuals

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dc.contributor.authorSharma, Gen_US
dc.contributor.authorNain, PSen_US
dc.contributor.authorSethi, Pen_US
dc.contributor.authorAhuja, Aen_US
dc.contributor.authorSharma, Sen_US
dc.date.accessioned2020-04-10T01:42:21Z
dc.date.available2020-04-10T01:42:21Z
dc.date.issued2019-04
dc.description.abstractBackground & objectives: Ghrelin is an orexigenic gut hormone expressed by the gastric fundus. Laparoscopic sleeve gastrectomy (LSG) procedure involves resection of the gastric fundus leading to a decreased appetite and weight loss. This study was undertaken to determine the levels of plasma ghrelin after sleeve gastrectomy in obese patients. Methods: The study was conducted on 90 morbidly obese patients [body mass index (BMI) >40 kg/m[2]] and severely obese patients (BMI >35/kg/m[2]) who underwent sleeve gastrectomy. The patients were followed up for six months. Weight loss parameters and plasma ghrelin levels were assessed pre- and postoperatively. Results: A significant weight loss and decrease in BMI were observed at three and six months postoperatively. A significant decrease in plasma ghrelin levels over six months of follow up postoperatively was also seen. Interpretation & conclusions: These preliminary findings indicated inhibition of ghrelin production after LSG leading to a decrease in the plasma ghrelin levels within a few days of surgery and sustainable weight loss in obese patients.en_US
dc.identifier.affiliationsDepartment of Physiology, Dayanand Medical College & Hospital, Ludhiana, Indiaen_US
dc.identifier.affiliationsDepartment of Surgery, Dayanand Medical College & Hospital, Ludhiana, Indiaen_US
dc.identifier.affiliationsDepartment of Gastrointestinal Surgery, Amrita Institute of Medical Sciences & Research, Kochi, Indiaen_US
dc.identifier.affiliationsDepartment of Community Medicine, Dayanand Medical College & Hospital, Ludhiana, Indiaen_US
dc.identifier.citationSharma G, Nain PS, Sethi P, Ahuja A, Sharma S. Plasma ghrelin levels after laparoscopic sleeve gastrectomy in obese individuals. Indian Journal of Medical Research. 2019 Apr; 149(4): 544-547en_US
dc.identifier.issn0971-5916
dc.identifier.issn0975-9174
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/195851
dc.languageenen_US
dc.publisherIndian Council of Medical Researchen_US
dc.relation.issuenumber4en_US
dc.relation.volume149en_US
dc.source.urihttps://dx.doi.org/10.4103/ijmr.IJMR_984_18en_US
dc.subjectGhrelinen_US
dc.subjectobeseen_US
dc.subjectsleeve gastrectomyen_US
dc.subjectweight lossen_US
dc.titlePlasma ghrelin levels after laparoscopic sleeve gastrectomy in obese individualsen_US
dc.typeJournal Articleen_US
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