Serum C3d levels in tropical pulmonary eosinophilia.

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dc.contributor.authorRay, Debidas
dc.contributor.authorSubramanyam, Sudha
dc.contributor.authorKrishna, S Hari
dc.contributor.authorRamanathan, V D
dc.date.accessioned2011-11-24T06:37:16Z
dc.date.available2011-11-24T06:37:16Z
dc.date.issued2011-04
dc.description.abstractBackground & objectives: Results of earlier studies to evaluate the possible role of complement system in tropical pulmonary eosinophilia (TPE) using classical methods like serum haemolyte component CH50, C3 and C4 levels were inconclusive. In this study we determined levels of serum C3d which is a catabolic fragment of C3, to find out any direct evidence of activation of the complement system in TPE. Methods: The study population consisted of 3 groups. Group A consisted of 37 patients with well characterized TPE. In group B, 26 patients with pulmonary eosinophilia had similar respiratory and haemotological features as in Group A but had associated worm infestation in stool. The control group consisted of 39 healthy volunteers. Serum C3d levels were determined by sandwich ELISA technique. Results: The serum C3d levels in TPE patients were not significantly different from those of the patients of group B or the normal controls. Interpretation & conclusions: Absence of significant change in serum C3d goes against the possibility of complement activation in TPE. Results of our study suggest that complement system is unlikely to play a pivotal role in pathogenesis of TPE.en_US
dc.identifier.citationRay Debidas, Subramanyam Sudha, Krishna S Hari, Ramanathan V D. Serum C3d levels in tropical pulmonary eosinophilia. Indian Journal of Medical Research. 2010 Apr; 131(4): 555-558.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135480
dc.language.isoenen_US
dc.source.urihttps://icmr.nic.in/ijmr/2010/april/0411.pdfen_US
dc.subjectComplementen_US
dc.subjectC3den_US
dc.subjecttropical pulmonary eosinophiliaresultsen_US
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCase-Control Studies
dc.subject.meshChild
dc.subject.meshComplement C3d --metabolism
dc.subject.meshEnzyme-Linked Immunosorbent Assay
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPulmonary Eosinophilia --blood
dc.subject.meshTropical Medicine
dc.titleSerum C3d levels in tropical pulmonary eosinophilia.en_US
dc.typeArticleen_US
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