Oral Selenium as an Adjunct in the Treatment of Acute Lower Respiratory Tract Infections in Children: A Double-Blind Randomized Controlled Trial

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dc.contributor.authorShaikh, Rubeena Jamiren_US
dc.contributor.authorJoshi, Trupti Amolen_US
dc.contributor.authorMundada, Smita Madhusudanen_US
dc.contributor.authorPawar, Shilpa Yashwanten_US
dc.contributor.authorMore, Prabha Bhaskar Khaireen_US
dc.date.accessioned2025-08-13T09:09:40Z
dc.date.available2025-08-13T09:09:40Z
dc.date.issued2025-05
dc.description.abstractOBJECTIVES To evaluate the role of oral selenium in clinical recovery of acute lower respiratory tract infec?ons (ALRTI) in under-five children. METHODS This double-blind, randomized controlled trial included children aged 6 months to 5 years hospitalised with ALRTI at a ter?ary care hospital. Par?cipants were randomized in 1:1 ra?o to receive oral selenium (20–30 mcg/day) or placebo, once daily un?l discharge, along with standard treatment. The primary outcome was the ?me for clinical recovery. The secondary outcomes were the dura?on of hospital stay, modes of oxygen support required and side effects of selenium. RESULTS A total of 60 children were randomized to either groups. The median (IQR) ?me required for clinical recovery was 72 (54, 144) h in the selenium group and 96 (54, 120) h in the placebo group ( P = 0.346). The median (IQR) dura?on of hospital stay was 6 (5, 7) days and 6 (6, 8) days in the selenium and placebo groups, respec?vely ( P = 0.680). Mechanical ven?la?on was required in 10 (16.6%) and 21 (35%) children in the selenium and placebo groups, respec?vely ( P = 0.020). No side effects were reported with the interven?on. CONCLUSIONS Oral selenium administered as an adjunct in a daily dose of 20–30 mcg orally for 5–7 days, does not reduce the ?me needed for clinical recovery or the dura?on of hospitaliza?on but reduces the need for mechanical ven?la?on in under-five children with ALRTI.en_US
dc.identifier.affiliationsDepartment of Pediatrics, Government Medical College Chhatrapati Sambhajinagar, Aurangabad, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, Government Medical College Chhatrapati Sambhajinagar, Aurangabad, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, Government Medical College Chhatrapati Sambhajinagar, Aurangabad, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, Government Medical College Chhatrapati Sambhajinagar, Aurangabad, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, Government Medical College Chhatrapati Sambhajinagar, Aurangabad, Maharashtra, India.en_US
dc.identifier.citationShaikh Rubeena Jamir, Joshi Trupti Amol, Mundada Smita Madhusudan, Pawar Shilpa Yashwant, More Prabha Bhaskar Khaire . Oral Selenium as an Adjunct in the Treatment of Acute Lower Respiratory Tract Infections in Children: A Double-Blind Randomized Controlled Trial. Indian Pediatrics. 2025 May; 62(5): 351-355en_US
dc.identifier.issn0019-6061
dc.identifier.issn0974-7559
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/251337
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber5en_US
dc.relation.volume62en_US
dc.source.urihttps://indianpediatrics.net/may2025/351.pdfen_US
dc.subjectPneumoniaen_US
dc.subjectOxygenen_US
dc.subjectUnder-fi ve childrenen_US
dc.subjectSodium selenateen_US
dc.titleOral Selenium as an Adjunct in the Treatment of Acute Lower Respiratory Tract Infections in Children: A Double-Blind Randomized Controlled Trialen_US
dc.typeJournal Articleen_US
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