Non invasive assessment of malignancy in solitary non palpable thyroid nodules: A comparative and complimentary evaluation of grey scale ultrasound and color doppler parameters –Way towards a new scoring system?

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dc.contributor.authorAggarwal, Abhisheken_US
dc.contributor.authorAggarwal, Jyotien_US
dc.contributor.authorAwasthi, Seemaen_US
dc.date.accessioned2019-11-16T07:16:25Z
dc.date.available2019-11-16T07:16:25Z
dc.date.issued2017-01
dc.description.abstractObjectives: To assess the comparative as well as collective role of various grey scale (GS) ultrasonography (USG) and color doppler (CD) parameters in distinguishing benign from malignant thyroid nodules. To suggest a scoring system for predicting malignancy in thyroid nodules using this array of parameters. Methods: 140 patients with non palpable thyroid nodules were examined by five GS USG and three CD parameters. The results were compared with histopathological examination and evaluated statistically. Each GS and CD parameter was evaluated individually as well as collectively, comparatively. Total score was calculated by assigning each of these eight parameters a score of 0 to 2. Results: Scoring used in this study showed sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), accuracy of 87.5%, 90.6%, 70%, 96.7% and 80% respectively. These parameters were 85.4%, 86.2%, 60%, 96%, 80% for CD and 69.2%, 71.9%, 50%, 85.2% and 64% for GS. Two GS USG features showing p value < 0.05 were poorly defined margins and thick incomplete halo while on CD Resistivity index (RI) was found to be very highly significant (p < 0.0001) and Pulsatility index (PI) was highly significant (p < 0.001). Conclusion: Scoring system proposed in this study proved better than GS or CD individually for predicting malignancy in thyroid nodules. Amongst various GS and CD parameters RI showed highest statistical significance. Overall CD showed better accuracy, sensitivity, specificity than GS USG.en_US
dc.identifier.affiliationsAssociate Professor, Radiology, TMMC& RC, Moradabad UP, Indiaen_US
dc.identifier.affiliationsAssociate Professor, Biochemistry MMIMS&R, Mullana, Ambala, Haryana, Indiaen_US
dc.identifier.affiliationsProfessor, Pathology, TMMC& RC, Moradabad, UP, Indiaen_US
dc.identifier.citationAggarwal Abhishek, Aggarwal Jyoti, Awasthi Seema. Non invasive assessment of malignancy in solitary non palpable thyroid nodules: A comparative and complimentary evaluation of grey scale ultrasound and color doppler parameters –Way towards a new scoring system?. Acta Medica International. 2017 Jan-Jun; 4(1): 1-6en_US
dc.identifier.issn2349-0578
dc.identifier.issn2349-0896
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/183727
dc.languageenen_US
dc.publisherTeerthanker Mahaveer Universityen_US
dc.relation.issuenumber1en_US
dc.relation.volume4en_US
dc.source.urihttps://doi.org/10.5530/ami.2017.4.1en_US
dc.subjectThyroid Ultrasounden_US
dc.subjectThyroid Doppleren_US
dc.subjectMalignancy in Thyroid Nodulesen_US
dc.subjectThyroid Nodules Ultra-sound Doppler Scoringen_US
dc.titleNon invasive assessment of malignancy in solitary non palpable thyroid nodules: A comparative and complimentary evaluation of grey scale ultrasound and color doppler parameters –Way towards a new scoring system?en_US
dc.typeJournal Articleen_US
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