Immunotherapy: Current indications and recommendations in the management of ocular allergy

Simple item page
dc.contributor.authorMahesh, Padukudru Ananden_US
dc.contributor.authorSamajdar, Shambo Samraten_US
dc.contributor.authorNagarajan, Sowmya Arudien_US
dc.contributor.authorMurthy, Greeshma Mandya Venkateshen_US
dc.contributor.authorMoitra, Saibalen_US
dc.date.accessioned2025-06-19T05:52:05Z
dc.date.available2025-06-19T05:52:05Z
dc.date.issued2025-04
dc.description.abstractAllergic diseases, including allergic conjunctivitis (AC), pose a significant health burden, affecting both developed and developing nations. Despite its importance, AC is often underreported, leading to underestimated incidence and prevalence. The coexistence of AC with allergic rhinitis and its comorbidity with asthma underscore its clinical relevance. The prevalence of nasal symptoms with eye symptoms related to eye allergy varies among different age groups and regions worldwide. Climatic factors, aeroallergens, and environmental exposure play significant roles in the prevalence of ocular allergies. Allergen immunotherapy (AIT) represents the only disease?modifying treatment for IgE?mediated allergic diseases. This review provides a comprehensive overview of the history, mechanisms, and evidence of AIT for ocular allergies, with a focus on AC. The primary routes of AIT, subcutaneous immunotherapy (SCIT), and sublingual immunotherapy (SLIT) are discussed in detail. The evidence for AIT in treating AC is extensive and demonstrates its effectiveness in alleviating ocular symptoms, reducing medication usage, and improving the quality of life in patients. Both SCIT and SLIT have shown positive results, with SLIT having a more favorable safety profile. Considerations for initiating and maintaining AIT, including adherence, financial burden, and treatment duration, are highlighted. In summary, AIT is a valuable treatment option for AC, offering long?term symptom relief and potential cost?effectiveness. By understanding the history, mechanisms, and evidence of AIT, healthcare providers can better manage ocular allergies and improve patient outcomes.en_US
dc.identifier.affiliationsDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, Indiaen_US
dc.identifier.affiliationsDiabetes and Allergy Asthma Therapeutics Specialty Clinic, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Paediatrics and Sub-Speciatilies, Sanjeevini Allergy and Paediatric Specialist Clinic and Kangaroo Care Hospitals and Narayana Netralaya, Bengaluru, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Centre for Excellence in Molecular Biology and Regenerative Medicine Laboratory, JSS (Jagadguru Sri Shivarathreeshwara) Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, Indiaen_US
dc.identifier.affiliationsDivision of Allergy and Immunology, Apollo Multispeciality Hospitals, Kolkata, West Bengal, Indiaen_US
dc.identifier.citationMahesh Padukudru Anand, Samajdar Shambo Samrat, Nagarajan Sowmya Arudi, Murthy Greeshma Mandya Venkatesh, Moitra Saibal. Immunotherapy: Current indications and recommendations in the management of ocular allergy. Indian Journal of Ophthalmology. 2025 Apr; 73(4): 526-536en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249871
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber4en_US
dc.relation.volume73en_US
dc.source.urihttps://doi.org/10.4103/IJO.IJO_2853_23en_US
dc.subjectAllergen immunotherapyen_US
dc.subjectallergic conjunctivitisen_US
dc.subjectimmune resistanceen_US
dc.subjectsubcutaneous immunotherapyen_US
dc.subjectsublingual immunotherapyen_US
dc.titleImmunotherapy: Current indications and recommendations in the management of ocular allergyen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ijo2025v73n4p526.pdf
Size:
1.39 MB
Format:
Adobe Portable Document Format
Download
Collections
Indian Journal of Ophthalmology